Skip to main content

Table 2 Genotype association between subjects

From: Association of HTRA1 and ARMS2 gene polymorphisms with response to intravitreal ranibizumab among neovascular age-related macular degenerative subjects

Gene variant

W/M

Subjects

WW

WM

MM

P valuea

W (%)

M (%)

P valuea

HWEb

OR (95% CI)

          

χ 2

P

 

ARMS2 rs10490924

G/T

nAMD

21 (14.5)

57 (39.3)

67 (46.2)

 

34.1

65.9

 

2.293

0.318

2.44

  

Controls

46 (31.7)

70 (48.3)

29 (20.0)

< 0.001*

55.9

44.1

< 0.001*

0.068

0.966

(1.75–3.42)

HTRA1 rs11200638

G/A

nAMD

19 (13.1)

47 (32.4)

79 (54.5)

 

29.3

70.7

 

6.823

0.033

1.52

  

Controls

15 (10.3)

82 (56.6)

48 (33.1)

< 0.001*

38.6

61.4

0.018*

5.386

0.068

(1.07–2.15)

  1. Data are presented as percentages in parentheses
  2. M risk allele, W non-risk allele, OR odds ratio, CI confidence interval, HWE Hardy-Weinberg equilibrium
  3. *Significant P value, P < 0.05
  4. aChi-square test
  5. bχ2 goodness-of-fit test
Back to article page

Human Genomics

ISSN: 1479-7364