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Table 3 Visual acuity and central retinal thickness outcome by genotype among nAMD subjects

From: Association of HTRA1 and ARMS2 gene polymorphisms with response to intravitreal ranibizumab among neovascular age-related macular degenerative subjects

   ARMS2 rs10490924 (n = 145) HTRA1 rs11200638 (n = 145)
GG GT TT P GG GA AA P
Total (n)   21 (14.5) 57 (39.3) 67 (46.2)   19 (13.1) 47 (32.4) 79 (54.5)  
Mean age (years)a   66.47 ± 7.31 70.35 ± 7.74 68.87 ± 7.25 0.122c 65.95 ± 7.46 69.87 ± 7.79 69.41 ± 7.26 0.137c
Gender Male 8 (38.1) 40 (70.2) 38 (56.7)   6 (31.6) 37 (78.7) 43 (54.4)  
Female 13 (61.9) 17 (29.8) 29 (43.3) 0.032c* 13 (68.4) 10 (21.3) 36 (45.6) 0.001c*
Mean BCVA (logMAR) a Baseline 0.59 ± 0.28 0.56 ± 0.28 0.56 ± 0.25 0.861b 0.59 ± 0.27 0.62 ± 0.28 0.53 ± 0.25 0.190b
3 months 0.58 ± 0.28 0.58 ± 0.26 0.61 ± 0.27 0.771b 0.58 ± 0.29 0.61 ± 0.27 0.59 ± 0.26 0.906b
6 months 0.45 ± 0.29 0.58 ± 0.28 0.62 ± 0.28 0.046b* 0.44 ± 0.31 0.58 ± 0.27 0.61 ± 0.29 0.044b*
Mean CRT (μM) a Baseline 417.8 ± 129.82 388.7 ± 143.95 369.5 ± 134.71 0.357c 431.5 ± 128.46 393.9 ± 151.47 366.7 ± 129.63 0.153c
3 months 343.9 ± 165.37 355.3 ± 131.49 353.6 ± 93.17 0.411b 350.3 ± 172.62 357.9 ± 128.46 350.5 ± 100.83 0.665b
6 months 323.6 ± 144.39 339.0 ± 129.48 400.1 ± 127.90 < 0.001b* 329.2 ± 150.19 341.7 ± 130.29 387.5 ± 129.89 0.008b*
Changes in BCVA (logMAR) a 3 months − 0.01 ± 0.21 0.02 ± 0.24 0.05 ± 0.19 0.263b − 0.003 ± 0.19 − 0.01 ± 0.24 0.06 ± 0.21 0.104b
6 months − 0.14 ± 0.27 0.03 ± 0.28 0.06 ± 0.29 0.011b* − 0.15 ± 0.26 − 0.03 ± 0.27 0.08 ± 0.29 0.002b*
Changes in CRT (μM) a 3 months − 73.9 ± 98.67 − 33.4 ± 126.33 − 15.8 ± 140.46 0.507c − 81.2 ± 101.09 − 36.1 ± 113.17 − 16.1 ± 143.46 0.141c
6 months − 94.2 ± 82.17 − 49.7 ± 145.18 30.6 ± 184.27 0.022c* − 102.4 ± 82.16 − 52.3 ± 145.09 20.8 ± 178.85 0.003c*
  1. Data are presented as percentages in parentheses
  2. CRT central retinal thickness, BCVA best-corrected visual acuity
  3. *Significant P value, P < 0.05
  4. aData presented as mean ± standard deviation (SD)
  5. bKruskal-Wallis test
  6. cMann-Whitney U test