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Table 1 Genetic pleiotropy and enrichment of functional deleteriousness among genetic loci associated with childhood BMI and adult cardiometabolic traits

From: Shared genetic underpinnings of childhood obesity and adult cardiometabolic diseases

Adult cardiometabolic trait

Genetic pleiotropy

Functional annotation enrichment

π11 (s.e.)

Pleiotropy test statistics

P value

π11 (s.e.)

Annotation test statistics

P value

Body mass index

0.055 (0.001)

23,690.45

< 10− 300

1.30 (0.04)

173.01

2.85 × 10−37

Coronary artery disease

0.01 (0)

1215.77

2.29 × 10−266

1.60 (0.13)

87.27

8.47 × 10−19

Fasting glucose

0 (0.001)

1.21

0.27

0.04 (2.74)

6.44

0.09

Fasting insulin

0.047 (0.003)

509.74

7.24 × 10−113

1.004 (0.22)

41.46

5.23 × 10−09

Hemoglobin A1c

0.006 (0)

87.12

1.02 × 10−20

2.52 (0.22)

48.73

1.49 × 10−10

HDL cholesterol

0.005 (0)

2151.79

< 10−300

1.54 (0.12)

88.39

4.86 × 10−19

Insulin secretion

0 (0)

0.89

0.35

7.31 (1.79)

38.69

2.01 × 10−08

Insulin sensitivity

0.013 (0.001)

393.57

1.38 × 10−87

1.54 (0.21)

45.63

6.81 × 10−10

LDL cholesterol

0.003 (0)

739.01

9.85 × 10−163

1.29 (0.20)

98.53

3.22 × 10−21

Myocardial infarction

0.01 (0)

887.48

5.16 × 10−195

1.68 (0.14)

58.51

1.22 × 10−12

Type 2 diabetes

0.007 (0)

855.26

5.23 × 10−188

1.37 (0.19)

65.95

3.14 × 10−14

Total cholesterol

0.005 (0)

1186.54

5.14 × 10−260

1.45 (0.15)

124.99

6.47 × 10−27

Triglycerides

0.003 (0)

1005.09

1.40 × 10−220

1.44 (0.17)

74.82

3.97 × 10−16

Waist circumference

0.026 (0)

14,809.27

< 10−300

1.43 (0.06)

112.69

2.89 × 10−24

Waist-to-hip ratio

0.019 (0)

5271.53

< 10− 300

1.60 (0.08)

113.88

1.61 × 10−24

  1. π11 is the probability of association of SNPs with both tested traits. q11/q00 is the ratio of the probability of jointly associated SNPs being functionally annotated to the probability of a null SNP (associated with neither trait) being functionally annotated