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Table 1 Genetic pleiotropy and enrichment of functional deleteriousness among genetic loci associated with childhood BMI and adult cardiometabolic traits

From: Shared genetic underpinnings of childhood obesity and adult cardiometabolic diseases

Adult cardiometabolic trait Genetic pleiotropy Functional annotation enrichment
π11 (s.e.) Pleiotropy test statistics P value π11 (s.e.) Annotation test statistics P value
Body mass index 0.055 (0.001) 23,690.45 < 10− 300 1.30 (0.04) 173.01 2.85 × 10−37
Coronary artery disease 0.01 (0) 1215.77 2.29 × 10−266 1.60 (0.13) 87.27 8.47 × 10−19
Fasting glucose 0 (0.001) 1.21 0.27 0.04 (2.74) 6.44 0.09
Fasting insulin 0.047 (0.003) 509.74 7.24 × 10−113 1.004 (0.22) 41.46 5.23 × 10−09
Hemoglobin A1c 0.006 (0) 87.12 1.02 × 10−20 2.52 (0.22) 48.73 1.49 × 10−10
HDL cholesterol 0.005 (0) 2151.79 < 10−300 1.54 (0.12) 88.39 4.86 × 10−19
Insulin secretion 0 (0) 0.89 0.35 7.31 (1.79) 38.69 2.01 × 10−08
Insulin sensitivity 0.013 (0.001) 393.57 1.38 × 10−87 1.54 (0.21) 45.63 6.81 × 10−10
LDL cholesterol 0.003 (0) 739.01 9.85 × 10−163 1.29 (0.20) 98.53 3.22 × 10−21
Myocardial infarction 0.01 (0) 887.48 5.16 × 10−195 1.68 (0.14) 58.51 1.22 × 10−12
Type 2 diabetes 0.007 (0) 855.26 5.23 × 10−188 1.37 (0.19) 65.95 3.14 × 10−14
Total cholesterol 0.005 (0) 1186.54 5.14 × 10−260 1.45 (0.15) 124.99 6.47 × 10−27
Triglycerides 0.003 (0) 1005.09 1.40 × 10−220 1.44 (0.17) 74.82 3.97 × 10−16
Waist circumference 0.026 (0) 14,809.27 < 10−300 1.43 (0.06) 112.69 2.89 × 10−24
Waist-to-hip ratio 0.019 (0) 5271.53 < 10− 300 1.60 (0.08) 113.88 1.61 × 10−24
  1. π11 is the probability of association of SNPs with both tested traits. q11/q00 is the ratio of the probability of jointly associated SNPs being functionally annotated to the probability of a null SNP (associated with neither trait) being functionally annotated