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Table 1 AS-SNPs detected associated to liver-specific GWAS traits

From: Studies of liver tissue identify functional gene regulatory elements associated to gene expression, type 2 diabetes, and other metabolic diseases

GWAS-associated traits

Number of AS-SNPs

Number of AS loci*

Blood protein levels

5

4

Type 2 diabetes

4

2

Obesity-related traits

3

2

Liver enzyme levels (gamma-glutamyl transferase)

2

1

Fibrinogen levels (smoking status, alcohol consumption, or BMI interaction)

2

1

Cholesterol, total

2

1

Fibrinogen

2

1

Response to hepatitis C treatment

1

1

C-reactive protein levels or total/LDL cholesterol levels (pleiotropy)

1

1

Serum metabolite levels

1

1

Primary biliary cholangitis

1

1

HDL cholesterol

1

1

Total

25

17

  1. *Loci defined as AS-SNPs within 1-Mb regions