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Table 1 AS-SNPs detected associated to liver-specific GWAS traits

From: Studies of liver tissue identify functional gene regulatory elements associated to gene expression, type 2 diabetes, and other metabolic diseases

GWAS-associated traits Number of AS-SNPs Number of AS loci*
Blood protein levels 5 4
Type 2 diabetes 4 2
Obesity-related traits 3 2
Liver enzyme levels (gamma-glutamyl transferase) 2 1
Fibrinogen levels (smoking status, alcohol consumption, or BMI interaction) 2 1
Cholesterol, total 2 1
Fibrinogen 2 1
Response to hepatitis C treatment 1 1
C-reactive protein levels or total/LDL cholesterol levels (pleiotropy) 1 1
Serum metabolite levels 1 1
Primary biliary cholangitis 1 1
HDL cholesterol 1 1
Total 25 17
  1. *Loci defined as AS-SNPs within 1-Mb regions