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Table 2 Clinical characteristics of participants genotyped using Axiom and MEGA arrays (stage 1b and 1c)

From: Genome-wide association study identifies novel loci for type 2 diabetes-attributed end-stage kidney disease in African Americans

 

WFSM-Axiom

WFSM-MEGA

T2D-ESKD

Non-diabetic non-nephropathy

T2D-lacking nephropathy

T2D-ESKD

Non-diabetic non-nephropathy

T2D-lacking nephropathy

Non-diabetic ESKD

N

1700

770

663

219

908

201

1910

Females (%)

56

49

64

49

59

62

41

Age (years)

62.0 ± 10.8

47.9 ± 12.0

55.7 ± 11.6

62.0 ± 11.0

44.8 ± 13.9

55.8 ± 9.5

55.4 ± 14.4

Age of onset of diabetes (years)

39.7 ± 12.8

–

46.2 ± 12.3

37.8 ± 9.6

–

43.7 ± 10.3

–

Duration of diabetes prior to ESKD (years)

19.1 ± 10.0

–

–

20.4 ± 9.5

–

–

–

Duration of ESKD (years)

3.6 ± 3.6

–

–

4.1 ± 3.1

–

–

6.2 ± 5.8

Fasting serum glucose (mg/dl)

184 ± 89

96 ± 22

163 ± 92

127 ± 33

96 ± 11

174 ± 62

90 ± 3

eGFR (ml/min/1.73m2)

–

96.0 ± 20.8

91.3 ± 19.7

–

85.9 ± 17.3

95.2 ± 17.3

–

Body mass index (kg/m2)

30.7 ± 7.1

29.6 ± 7.4

33.1 ± 7.8

30.8 ± 7.0

29.7 ± 6.6

33.0 ± 6.5

27.8 ± 7.2

  1. Categorical data expressed as percentage; continuous data as mean ± SD
  2. Abbreviations: T2D type 2 diabetes, ESKD end-stage kidney disease, N number, eGFR estimated glomerular filtration rate