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Table 3 Genome-wide significant T2D-ESKD associations (P < 5 × 10−8) in baseline model

From: Genome-wide association study identifies novel loci for type 2 diabetes-attributed end-stage kidney disease in African Americans

Lead variant CHR POS Locus Effect/other alleles Stage 1a (1513 T2D-ESKD cases vs. 5299 non-diabetic non-nephropathy controls) Stage 1b (1700 T2D-ESKD cases vs. 770 non-diabetic non-nephropathy controls) Stage 1c (219 T2D-ESKD cases vs. 908 non-diabetic non-nephropathy controls) Stage 2: Meta-analysis (3432 T2D-ESKD cases vs. 6977 non-diabetic non-nephropathy controls)
EAF OR (95% CI) P Info EAF OR (95% CI) P Info EAF OR (95% CI) P Info EAF OR (95% CI) P HetP
rs72858591 2 151711452 RND3/RBM43 C/T 0.10 1.55 (1.33,1.8) 1.32E−08 0.96 0.09 1.19 (0.92,1.54) 0.18 0.98 0.10 1.14 (0.72,1.82) 0.57 0.97 0.10 1.43 (1.26,1.62) 4.54E−08 0.15
rs58627064 3 165051826 SLITRK3 T/G 0.07 1.84 (1.53,2.2) 4.38E−11 0.91 0.06 1.19 (0.87,1.64) 0.27 0.97 0.06 1.25 (0.7,2.23) 0.46 1.00 0.06 1.62 (1.39,1.89) 6.81E−10 0.045
rs142563193 17 77667171 ENPP7 A/G 0.22 0.69 (0.6,0.78) 3.27E−08 0.64 0.23 0.81 (0.68,0.96) 0.018 0.97 0.25 0.91 (0.66,1.26) 0.57 0.97 0.23 0.74 (0.67,0.82) 1.24E−08 0.15
rs142671759 17 77706698 ENPP7 C/T 0.03 2.82 (2.05,3.87) 1.53E−10 0.73 0.02 1.15 (0.62,2.12) 0.66 0.82 0.02 1.53 (0.57,4.13) 0.40 0.92 0.02 2.26 (1.72,2.97) 5.53E−09 0.029
rs4807299 19 2570002 GNG7 A/C 0.05 1.95 (1.58,2.41) 7.31E−10 0.79 0.04 1.12 (0.76,1.65) 0.56 0.88 0.05 1.16 (0.58,2.32) 0.68 0.92 0.05 1.67 (1.4,2) 3.21E−08 0.028
rs9622363 22 36656555 APOL1 A/G 0.46 0.78 (0.7,0.85) 2.55E−07 0.87 0.44 0.77 (0.66,0.89) 0.00040 1.00 0.48 0.77 (0.58,1.03) 0.08 0.97 0.45 0.77 (0.72,0.84) 1.42E−10 0.995
  1. Baseline model: adjusted for age, sex, and PC1, APOL1 risk genotype carriers were included
  2. Abbreviations: T2D type 2 diabetes, ESKD end-stage kidney disease, CHR chromosome, POS position, EAF effect allele frequency, OR odds ratio, CI confidence interval, P P value, Info imputation quality, HetP heterogeneity P value