Table 1 Characteristics of study populations by post-RT pain

From: Genome-wide enriched pathway analysis of acute post-radiotherapy pain in breast cancer patients: a prospective cohort study

Variable	Categories			Post-RT pain
		Total		No (score < 4)		Yes (score ≥ 4)
		N	%	N	%	N	%	p ¹	p ²
Study population		1112	100	786	71	326	29
Study site	UM	377	34	243	64	134	36	0.001	0.340
Study site	WFU	735	66	543	74	192	26
Race/ethnicity	AA	296	27	194	66	102	34	< 0.001	0.315
	HW	401	36	265	66	136	34
	NHW	357	32	282	79	75	21
	Other	58	5	45	78	13	22
Age at consent (years)	< 50	283	25	175	62	108	38	<.0001	<.0001
	50–59	372	34	247	66	125	34
	≥ 60	457	41	364	80	93	20
BMI (kg/m²)	< 25	257	23	208	81	49	19	< .0001	0.002
	25–29.99	357	32	263	74	94	26
	≥ 30	498	45	315	63	183	37
Smoking history	Never	706	64	514	73	192	27	0.033	0.026
Smoking history	Ever	390	35	260	67	130	33
No. of comorbidity³	0	464	42	337	73	127	27	0.035	0.001
	1	378	34	275	73	103	27
	≥ 2	270	24	174	64	96	36
Tumor stage	0	217	20	159	73	58	27	0.077	–
	I	528	47	384	73	144	27
	II	234	21	161	69	73	31
	III–IV	132	12	82	62	50	38
ER	Positive	894	80	632	71	262	29	0.957	–
ER	Negative	217	20	153	71	64	29
PR	Positive	767	69	533	69	234	31	0.178	–
PR	Negative	343	31	252	73	91	27
HER2	Positive	143	13	106	74	37	26	0.283	–
HER2	Negative	798	72	556	70	242	30
Triple negative	No	964	87	687	71	277	29	0.248	–
Triple negative	Yes	134	12	89	66	45	34
Surgery	Lumpectomy	959	86	698	73	261	27	< .0.001	0.023
Surgery	Mastectomy	153	14	88	58	65	42
Chemotherapy	No	610	55	441	72	169	28	0.193	–
Chemotherapy	Yes	502	45	345	69	157	31
Hormonal therapy	No	785	71	570	73	215	27	0.029	0.587
Hormonal therapy	Yes	327	29	216	66	111	34
RT fractionation	Conventional	972	87	670	69	302	31	0.003	0.414
	Hypo	138	13	114	83	24	17
	Partial	2	0.1	2	100	.	.
RT dose (Gy)	< 60	266	24	205	77	61	23	0.010	–
RT dose (Gy)	≥ 60	834	75	574	69	260	31
Boost	No	121	11	94	78	27	22	0.078	–
Boost	Yes	979	88	685	70	294	30
Pre-RT pain score	< 4	936	84	715	76	221	24	< .0001	< .0001
Pre-RT pain score	≥ 4	151	14	57	38	94	62

¹p values from chi-square or Fisher’s exact test. Significant findings are in italics
²p values from multivariable logistic regression adjusting for other variables in tables
³The number of comorbidities, sum of 12 patient-reported comorbid conditions: diabetes, hypertension, heart disease, lung disease, thyroid condition, cirrhosis liver, stroke, chronic bronchitis, hepatitis, tuberculosis, and 2 others. AA African American; HW Hispanic Whites; NHW = non-Hispanic Whites; BMI body mass index

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