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Table 2 Top 30 SNPs from genome-wide association study of post-RT pain among breast cancer patients

From: Genome-wide enriched pathway analysis of acute post-radiotherapy pain in breast cancer patients: a prospective cohort study

   

Allele

      

Chr

SNP

BP

Minor

Major

MAF

OR1

95% CI

Pvalue1

Nearest gene

17

rs16970540

33,338,447

T

C

0.10

2.20

1.59

3.04

1.73E-06

RFFL, LIG3

13

rs4584690

95,680,132

T

C

0.18

1.85

1.42

2.42

5.46E-06

ABCC4(MRP4)

13

rs7335912

95,667,680

G

A

0.19

1.80

1.39

2.33

7.81E-06

ABCC4(MRP4)

23

rs73633565

13,477,311

G

A

0.16

1.90

1.43

2.52

8.06E-06

EGFL6

18

rs986117

44,128,503

C

A

0.36

1.62

1.31

2.01

1.04E-05

LOXHD1

3

rs6800849

11,790,188

A

C

0.17

1.84

1.40

2.41

1.15E-05

VGLL4

2

rs13031207

226,076,914

G

A

0.23

1.72

1.35

2.20

1.30E-05

DOCK10

17

rs10083888

33,402,980

T

C

0.11

2.00

1.47

2.73

1.30E-05

RFFL

7

rs1108228

51,787,366

A

G

0.46

1.61

1.30

1.99

1.40E-05

COBL

9

rs10901329

133,924,008

G

A

0.43

0.61

0.49

0.76

1.41E-05

LAMC3

15

rs4497630

30,276,341

A

G

0.26

0.57

0.45

0.74

1.62E-05

FAM7A3

14

rs11849204

34,332,971

G

A

0.11

1.98

1.45

2.70

1.62E-05

NPAS3

11

rs76647546

88,929,531

G

A

0.06

2.57

1.67

3.97

1.84E-05

TYR

7

rs12374901

15,024,954

T

C

0.43

0.62

0.50

0.77

1.88E-05

DGKB

9

rs10973146

3,706,109

G

A

0.06

2.42

1.61

3.65

2.13E-05

GLIS3

13

rs17189292

95,685,572

G

A

0.13

1.96

1.44

2.68

2.21E-05

ABCC4(MRP4)

6

rs72904381

83,130,109

C

T

0.45

0.63

0.51

0.78

2.30E-05

TPBG

9

rs2275139

133,924,072

C

T

0.43

0.62

0.50

0.78

2.35E-05

LAMC3

11

rs10901897

50,199,387

C

T

0.34

0.61

0.48

0.76

2.45E-05

LOC441601

2

rs2278358*

43,968,167

A

G

0.12

1.90

1.412

2.569

2.49E-05

PLEKHH2

3

rs717228

60,602,895

C

T

0.17

0.52

0.38

0.70

2.55E-05

FHIT

4

rs10023531

12,357,990

A

G

0.43

1.56

1.27

1.92

2.70E-05

HS3ST1

3

rs79082706

60,614,582

G

A

0.16

0.51

0.38

0.70

2.86E-05

FHIT

2

rs1443663

226,074,083

A

C

0.25

1.65

1.30

2.10

3.25E-05

DOCK10

13

rs4148524

95,767,333

C

T

0.14

1.84

1.38

2.45

3.45E-05

ABCC4(MRP4)

11

rs10082560

50,276,354

C

G

0.35

0.61

0.48

0.77

3.49E-05

LOC441601

13

rs12853814

95,720,188

C

T

0.13

1.93

1.41

2.64

3.55E-05

ABCC4(MRP4)

17

rs7214759

35,261,346

G

C

0.20

1.68

1.31

2.15

3.71E-05

LHX1

7

rs2731551

18,277,585

T

C

0.33

1.58

1.27

1.95

3.77E-05

HDAC9

7

rs596699

18,351,391

A

C

0.34

1.57

1.26

1.94

3.82E-05

HDAC9

  1. OR and p values from multivariable logistic regression analysis assuming additive genetic model
  2. Chr = chromosome, SNP = single-nucleotide polymorphism, BP = base position based on hg19/GRCh37, MAF = minor allele frequency, OR = odds ratio, CI = confidence intervals