Table 3 Top 30 genes from PLINK-set based test of post-RT pain among breast cancer patients
Gene symbol | Chr | Entrez ID | Gene name | P (gene) | No. SNPs within a gene | No. SNPs with p < 0.05 | No. SNPs with p < 0.05 and R2 < 0.5 | Top SNP |
|---|---|---|---|---|---|---|---|---|
EIF4G1 | 3q27.1 | 1981 | Eukaryotic translation initiation factor 4 Gamma 1 | 2.00E-04 | 28 | 1 | 1 | rs4912540 |
FAM131A | 3q27.1 | 131,408 | Family with sequence similarity 131 member A | 2.00E-04 | 22 | 1 | 1 | rs4912540 |
GRID2IP | 7p22.1 | 392,862 | Glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1, delphilin | 2.00E-04 | 31 | 1 | 1 | rs73674133 |
NMUR2 | 5q33.1 | 56,923 | Neuromedin U receptor 2 | 2.00E-04 | 22 | 1 | 1 | rs11739168 |
OR10V1 | 11q12.1 | 390,201 | Olfactory receptor family 10 subfamily V member 1 | 2.00E-04 | 13 | 2 | 1 | rs7937162 |
CYP4F22 | 19p13.12 | 126,410 | Cytochrome P450 family 4 subfamily F member 22 | 3.00E-04 | 54 | 1 | 1 | rs73514704 |
LECT1 | 13q14.3 | 11,061 | Leukocyte cell-derived chemotaxin 1, chondromodulin-1 | 4.00E-04 | 23 | 9 | 4 | rs3759509 |
LDHAL6B | 15q22.2 | 92,483 | Lactate dehydrogenase A like 6B | 5.00E-04 | 38 | 7 | 1 | rs11852359 |
PPP2R3B | Xp22.33 | 28,227 | Protein phosphatase 2 regulatory subunit B″beta | 0.0007 | 38 | 1 | 1 | rs28485241 |
PRKCDBP | 11p15.4 | 112,464 | Protein kinase C delta-binding protein | 0.0007 | 38 | 1 | 1 | rs4604857 |
TRIM64C | 11p11.12 | 646,754 | Tripartite motif containing 64C | 0.0007 | 2 | 1 | 1 | rs1819409 |
OR52N1 | 11p15.4 | 79,473 | Olfactory receptor family 52 subfamily N member 1 | 0.0008 | 14 | 10 | 1 | rs11607346 |
PDE4D | 5q12.1 | 5144 | Phosphodiesterase 4D | 0.0008 | 719 | 41 | 18 | rs1498599 |
PRPH2 | 6p21.1 | 5961 | Peripherin 2 | 0.0008 | 28 | 1 | 1 | rs200618579 |
RFFL | 17q12 | 117,584 | Ring finger and FYVE like domain containing E3 ubiquitin protein ligase | 0.0008 | 27 | 10 | 4 | rs16970540 |
OR4C12 | 11p11.12 | 283,093 | Olfactory receptor family 4 subfamily C member 12 | 0.0010 | 1 | 1 | 1 | rs4242812 |
MMADHC | 2q23.2 | 27,249 | Methylmalonic aciduria and homocystinuria, CblD type | 0.0011 | 17 | 1 | 1 | rs13027589 |
OR4A47 | 11p11.2 | 403,253 | Olfactory receptor family 4 subfamily A member 47 | 0.0011 | 6 | 3 | 2 | rs7103557 |
MPO | 17q22 | 4353 | Myeloperoxidase | 0.0012 | 19 | 1 | 1 | rs8178409 |
OSBP | 20q13.33 | 9885 | Oxysterol-binding protein | 0.0012 | 9 | 1 | 1 | rs4938923 |
ANAPC13 | 3q22.2 | 25,847 | Anaphase promoting complex subunit 13 | 0.0012 | 18 | 1 | 1 | rs75858178 |
CEP63 | 3q22.2 | 80,254 | Centrosomal protein 63 | 0.0013 | 29 | 1 | 1 | rs75858178 |
ROD1 | 9q32 | 9991 | Regulator of differentiation 1 | 0.0014 | 33 | 20 | 2 | rs10817314 |
SLC20A2 | 8p11.21 | 6575 | Solute carrier family 20 member 2 | 0.0015 | 33 | 2 | 1 | rs7845666 |
MAP4K3 | 2p22.1 | 8491 | Mitogen-activated protein kinase kinase kinase kinase 3 | 0.0016 | 52 | 1 | 1 | rs17508058 |
MGST3 | 1q24.1 | 4259 | Microsomal glutathione S-transferase 3 | 0.0016 | 60 | 3 | 1 | rs55977919 |
CLRN2 | 4p15.32 | 645,104 | Clarin 2 | 0.0017 | 719 | 41 | 18 | rs1498599 |
FOLH1 | 11q14.3 | 219,595 | Folate hydrolase 1 | 0.0017 | 11 | 5 | 3 | rs679470 |
GUCY1A3 | 4q32.1 | 2982 | Guanylate cyclase 1 soluble subunit alpha | 0.0018 | 77 | 1 | 1 | rs62327005 |
UNC119B | 12q24.31 | 84,747 | Unc-119 lipid-binding chaperone B | 0.0018 | 27 | 1 | 1 | rs12825376 |