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Table 4 Top pathways enriched in patients with post-RT pain in breast cancer patients from DAVID functional annotation module analysis

From: Genome-wide enriched pathway analysis of acute post-radiotherapy pain in breast cancer patients: a prospective cohort study

Cluster

Category

Term

No. genes in a term

Fold enrichment1

p value2

FDR3

1

GOTERM_BP_DIRECT

GO:0052697~xenobiotic glucuronidation

9

19.81952

3.45E-10

9.46E-07

GOTERM_BP_DIRECT

GO:2001030~negative regulation of cellular glucuronidation

8

19.81952

6.14E-09

8.43E-06

GOTERM_BP_DIRECT

GO:1904224~negative regulation of glucuronosyltransferase activity

8

19.81952

6.14E-09

8.43E-06

GOTERM_BP_DIRECT

GO:0045922~negative regulation of fatty acid metabolic process

8

17.61735

2.64E-08

2.42E-05

GOTERM_BP_DIRECT

GO:0052695~cellular glucuronidation

8

10.57041

3.62E-06

0.001983

GOTERM_BP_DIRECT

GO:0052696~flavonoid glucuronidation

9

8.494079

4.53E-06

0.002071

GOTERM_MF_DIRECT

GO:0015020~glucuronosyltransferase activity

9

7.057233

2.18E-05

0.019001

GOTERM_MF_DIRECT

GO:0001972~retinoic acid binding

8

6.818583

1.04E-04

0.04456

KEGG_PATHWAY

hsa00053:Ascorbate and aldarate metabolism

9

6.071802

6.39E-05

0.016351

KEGG_PATHWAY

hsa00040:Pentose and glucuronate interconversions

10

5.159047

8.29E-05

0.007101

KEGG_PATHWAY

hsa00860:Porphyrin and chlorophyll metabolism

11

4.706058

7.16E-05

0.009189

KEGG_PATHWAY

hsa05204:Chemical carcinogenesis

13

3.081485

8.48E-04

0.053271

KEGG_PATHWAY

hsa00982:Drug metabolism - cytochrome P450

12

3.189229

0.001097

0.055041

2

GOTERM_BP_DIRECT

GO:0050911~detection of chemical stimulus involved in sensory perception of smell

37

2.020171

8.21E-05

0.031689

GOTERM_MF_DIRECT

GO:0004984~olfactory receptor activity

37

1.992656

1.09E-04

0.03161

KEGG_PATHWAY

hsa04740:Olfactory transduction

36

1.730048

0.001446

0.060346

GOTERM_MF_DIRECT

GO:0004930~G-protein coupled receptor activity

48

1.589467

0.0017

0.312315

  1. 1The fold enrichment is defined as the ratio of the two proportions; one is the proportion of genes in your list belong to certain pathway, and the other is the proportion of genes in the background information (i.e., universe genes) that belong to that pathway
  2. 2p values from modified Fisher’s exact test
  3. 3FDR, false discovery rate from Benjamini and Hochberg
  4. DAVID = Database for Annotation, Visualization and Integrated Discovery, GO = Gene Ontology, KEGG = The Kyoto Encyclopedia of Genes and Genomes
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Human Genomics

ISSN: 1479-7364