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Table 3 Mean leukocyte telomere length (kb) according to H. pylori sero-status and serological evidence of atrophic gastritis

From: Helicobacter pylori infection, serum pepsinogens as markers of atrophic gastritis, and leukocyte telomere length: a population-based study

  Total Mean (SD) Mean difference (95% CI) p value
H. pylori IgG sero-status     0.016*
H. pylori negative 154 6.65 (0.66) Reference  
H. pylori positive 780 6.78 (0.60) 0.13 (0.02, 0.24)  
H. pylori/CagA IgG sero-status df = 2    0.023**
H. pylori negative 154 6.65 (0.66) Reference  
H. pylori positive CagA negative 452 6.76 (0.60) 0.1 (− 0.01, 0.22) 0.19***
H. pylori positive CagA positive 328 6.82 (0.59) 0.16 (0.05, 0.28) 0.018***
Atrophic gastritis (PGI < 30 μg/L or PGI:PGII < 3.0)§     0.011*
 No 846 6.78 (0.60) − 0.18 (− 0.32, − 0.04)  
 Yes 81 6.60 (0.65) Reference  
H. pylori sero-status/atrophic gastritis**** § df = 3    0.002**
H. pylori negative no atrophic gastritis 115 6.72 (0.63) Reference  
H. pylori positive no atrophic gastritis 731 6.79 (0.60) 0.07 (− 0.05, 0.18) 1.0****
H. pylori positive plus atrophic gastritis 44 6.77 (0.58) 0.05 (− 0.16, 0.26) 1.0****
Past H. pylori infection (IgG sero-negatives) plus atrophic gastritis 37 6.40 (0.67) − 0.32 (− 0.55, − 0.10) 0.028****
  1. CagA cytotoxin-associated gene A; CI confidence intervals; df degrees of freedom; IgG immunoglobulin G; PG pepsinogen; SD standard deviation
  2. *p value by Student’s t test
  3. **ANOVA for the difference between the groups
  4. ***Bonferroni for multiple comparisons correction compared to H. pylori-negative participants
  5. ****Bonferroni for multiple comparisons correction compared to participants who were H. pylori negative and no atrophic gastritis. H. pylori positive no atrophic gastritis vs. past H. pylori infection plus atrophic gastritis (p = 0.001). H. pylori positive plus atrophic gastritis vs. past H. pylori infection (IgG sero-negatives) plus atrophic gastritis (p = 0.037)
  6. §Information on atrophic gastritis was missing for 7 participants