Helicobacter pylori infection, serum pepsinogens as markers of atrophic gastritis, and leukocyte telomere length: a population-based study

Table 4 Multiple linear regression model of adjusted associations of demographic factors, H. pylori sero-status, and serological evidence of atrophic gastritis with leukocyte telomere length (kb)

	Beta coefficient (95% CI)	p value
Sex
Males	− 0.08 (− 0.15, − 0.01)	0.032
Females	Reference
Age, years
27–34	Reference
35–44	− 0.19 (− 0.31, − 0.06)	0.003
45–54	− 0.39 (− 0.51, − 0.26)	< 0.001
55–64	− 0.56 (− 0.69, − 0.44)	< 0.001
65–78	− 0.76 (− 0.89, − 0.64)	< 0.001
Religiosity
Religious	− 0.07 (− 0.14, 0.01)	0.078
Traditional/secular	Reference
H. pylori sero-status/atrophic gastritis^*
H. pylori negative no atrophic gastritis	Reference
H. pylori positive no atrophic gastritis	0.05 (− 0.06, 0.16)	0.3
H. pylori positive plus atrophic gastritis	0.16 (− 0.03, 0.35)	0.10
Past H. pylori infection (IgG sero-negatives) plus atrophic gastritis	− 0.21 (− 0.41, − 0.001)	0.049

CI confidence intervals; IgG immunoglobulin G
^*Atrophic gastritis was defined as serum pepsinogen (PG) I < 30 μg/L or PGI:PGII < 3.0
Model summary: adjusted R² = 0.198, degrees of freedom = 9, (F statistic = 26.24), p < 0.001
Adjusted for the variables in the table

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