TY - JOUR AU - Maleki, Farhad AU - Ovens, Katie AU - McQuillan, Ian AU - Kusalik, Anthony J. PY - 2019 DA - 2019/10/22 TI - Size matters: how sample size affects the reproducibility and specificity of gene set analysis JO - Human Genomics SP - 42 VL - 13 IS - 1 AB - Gene set analysis is a well-established approach for interpretation of data from high-throughput gene expression studies. Achieving reproducible results is an essential requirement in such studies. One factor of a gene expression experiment that can affect reproducibility is the choice of sample size. However, choosing an appropriate sample size can be difficult, especially because the choice may be method-dependent. Further, sample size choice can have unexpected effects on specificity. SN - 1479-7364 UR - https://doi.org/10.1186/s40246-019-0226-2 DO - 10.1186/s40246-019-0226-2 ID - Maleki2019 ER -