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Table 1 Significantly enriched gene sets

From: Three miRNAs cooperate with host genes involved in human cardiovascular disease

Tissue Gene set name: description FDR q value
miR-3182, CDH13
 Cardiac muscle Go_intracellular_vesicle: any vesicle that is part of the intracellular region. 0.0172
Kim_bipolar_disorder_oligodendrocyte_density_corr_up: genes whose expression significantly and positively correlated with oligodendrocyte density in layer VI of BA9 brain region in patients with bipolar disorder. 0.0172
Go_trans_golgi_network_membrane: the lipid bilayer surrounding any of the compartments that make up the trans-Golgi network. 0.0172
Module_12: spinal cord (neurodevelopment) genes. 0.0274
Go_regulation_of_cardiac_muscle_cell_contraction: any process that modulates the frequency, rate, or extent of cardiac muscle cell contraction. 0.0274
Go_regulation_of_cardiac_muscle_cell_contraction: any process that modulates the frequency, rate, or extent of cardiac muscle cell contraction. 0.0274
 Vascular endothelium Baker_hematopoiesis_stat3_targets: selected genes downregulated in response to the Ras inhibitor salirasib in a panel of cancer cell lines with constantly active HRAS. 0.027
Go_angiogenesis: blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. 0.04
miR-6863, SLC12A3
 Cardiac muscle GO_NEURON_PART: any constituent part of a neuron, the basic cellular unit of nervous tissue. 0.048
miR-5582, CKAP5
 Cardiac muscle Simbulan_parp1_targets_dn: genes downregulated in embryonic fibroblast cells from PARP1 knockout mice. 9 × 10−10
Pujana_chek2_pcc_network: genes constituting the CHEK2-pcc network of transcripts whose expression positively correlates with that of CHEK2. 2 × 10−9
 Vascular endothelium Blum_response_to_salirasib_dn: selected genes downregulated in response to the Ras inhibitor salirasib in a panel of cancer cell lines with constantly active HRAS. 5 × 10−27
Markey_rb1_acute_lof_up: Genes upregulated in adult fibroblasts with inactivated RB1 by cre-lox: acute loss of function of RB1. 5 × 10−25
 Heart Blum_response_to_salirasib_dn: selected genes downregulated in response to the Ras inhibitor salirasib in a panel of cancer cell lines with constantly active HRAS. 5 × 10−25
Berenjeno_transformed_by_RHOA_up: genes upregulated in fibroblast cells transformed by expression of constitutively active (q63l) form of RHOA off plasmid vector. 3 × 10−20