Table 1 Significantly enriched gene sets
From: Three miRNAs cooperate with host genes involved in human cardiovascular disease
Tissue | Gene set name: description | FDR q value |
|---|---|---|
miR-3182, CDH13 | ||
 Cardiac muscle | Go_intracellular_vesicle: any vesicle that is part of the intracellular region. | 0.0172 |
Kim_bipolar_disorder_oligodendrocyte_density_corr_up: genes whose expression significantly and positively correlated with oligodendrocyte density in layer VI of BA9 brain region in patients with bipolar disorder. | 0.0172 | |
Go_trans_golgi_network_membrane: the lipid bilayer surrounding any of the compartments that make up the trans-Golgi network. | 0.0172 | |
Module_12: spinal cord (neurodevelopment) genes. | 0.0274 | |
Go_regulation_of_cardiac_muscle_cell_contraction: any process that modulates the frequency, rate, or extent of cardiac muscle cell contraction. | 0.0274 | |
Go_regulation_of_cardiac_muscle_cell_contraction: any process that modulates the frequency, rate, or extent of cardiac muscle cell contraction. | 0.0274 | |
 Vascular endothelium | Baker_hematopoiesis_stat3_targets: selected genes downregulated in response to the Ras inhibitor salirasib in a panel of cancer cell lines with constantly active HRAS. | 0.027 |
Go_angiogenesis: blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. | 0.04 | |
miR-6863, SLC12A3 | ||
 Cardiac muscle | GO_NEURON_PART: any constituent part of a neuron, the basic cellular unit of nervous tissue. | 0.048 |
miR-5582, CKAP5 | ||
 Cardiac muscle | Simbulan_parp1_targets_dn: genes downregulated in embryonic fibroblast cells from PARP1 knockout mice. | 9 × 10−10 |
Pujana_chek2_pcc_network: genes constituting the CHEK2-pcc network of transcripts whose expression positively correlates with that of CHEK2. | 2 × 10−9 | |
 Vascular endothelium | Blum_response_to_salirasib_dn: selected genes downregulated in response to the Ras inhibitor salirasib in a panel of cancer cell lines with constantly active HRAS. | 5 × 10−27 |
Markey_rb1_acute_lof_up: Genes upregulated in adult fibroblasts with inactivated RB1 by cre-lox: acute loss of function of RB1. | 5 × 10−25 | |
 Heart | Blum_response_to_salirasib_dn: selected genes downregulated in response to the Ras inhibitor salirasib in a panel of cancer cell lines with constantly active HRAS. | 5 × 10−25 |
Berenjeno_transformed_by_RHOA_up: genes upregulated in fibroblast cells transformed by expression of constitutively active (q63l) form of RHOA off plasmid vector. | 3 × 10−20 | |