Table 1 List and characteristics of the 48 sequenced genes (obtained from GeneCards® database)
From: Novel analytical methods to interpret large sequencing data from small sample sizes
Gene symbol | Chromosomal location | Gene name |
|---|---|---|
Plasma proteins, membrane transporters, and regulators (n = 10) | ||
ABCB1 | 7q21.12 | ATP-binding cassette subfamily B member 1 |
ABCC2 | 10q24 | ATP-binding cassette subfamily C member 2 |
ABCG2 | 4q22.1 | ATP-binding cassette subfamily G member 2 (Junior blood group) |
HFE | 6p21.3 | Hemochromatosis |
HIF1A | 14q23.2 | Hypoxia inducible factor 1 alpha subunit |
ORM1 | 9q32 | Orosomucoid 1 |
SLC22A1 | 6q25.3 | Solute carrier family 22 member 1 |
SLC22A4 | 5q23.3 | Solute carrier family 22 member 4 |
SLCO1A2 | 12p12 | Solute carrier organic anion transporter family member 1A2 |
SLCO1B1 | 12p12 | Solute carrier organic anion transporter family member 1B1 |
Metabolism enzymes and regulators (n = 12) | ||
CYP1A1 | 15q24.1 | Cytochrome P450 family 1 subfamily A member 1 |
CYP1A2 | 15q24.1 | Cytochrome P450 family 1 subfamily A member 2 |
CYP2C19 | 10q24 | Cytochrome P450 family 2 subfamily C member 19 |
CYP2C8 | 10q24.1 | Cytochrome P450 family 2 subfamily C member 8 |
CYP2C9 | 10q24.1 | Cytochrome P450 family 2 subfamily C member 9 |
CYP2D6 | 22q13.1 | Cytochrome P450 family 2 subfamily D member 6 |
CYP3A4 | 7q21.1 | Cytochrome P450 family 3 subfamily A member 4 |
CYP3A5 | 7q21.1 | Cytochrome P450 family 3 subfamily A member 5 |
NR1I2 | 3q12-q13.3 | Nuclear receptor subfamily 1 group I member 2 |
NR1I3 | 1q23.3 | Nuclear receptor subfamily 1 group I member 3 |
UGT1A1 | 2q37.1 | UDP glucuronosyltransferase family 1 member A1 |
UGT1A9 | 2q37 | UDP glucuronosyltransferase family 1 member A9 |
Cell cycle and proliferation (n = 5) | ||
CCND1 | 11q13 | Cyclin D1 |
PPP2R2A | 8p21.2 | Protein phosphatase 2 regulatory subunit B. alpha |
RPA1 | 17p13.3 | Replication protein A1 |
RPA2 | 1p35 | Replication protein A2 |
RPA3 | 7p21.3 | Replication protein A3 |
DNA repair (n = 10) | ||
ERCC2 | 19q13.3 | Excision repair cross-complementation group 2 |
ERCC3 | 2q21 | Excision repair cross-complementation group 3 |
ERCC4 | 16p13.3 | Excision repair cross-complementation group 4 |
ERCC5 | 13q22-q34 | Excision repair cross-complementation group 5 |
ERCC6 | 10q11 | Excision repair cross-complementation group 6 |
ERCC8 | 5q12.1 | Excision repair cross-complementation group 8 |
LIG1 | 19q13.33 | DNA ligase 1 |
RAD23B | 9p31.2 | RAD23 homolog B. nucleotide excision repair protein |
XPA | 9p22.3 | Xeroderma pigmentosum complementation group A |
XPC | 3p25.1 | Xeroderma pigmentosum complementation group C |
Cytokine pathways (n = 6) | ||
CXCL8 | 4q13-q21 | C-X-C motif chemokine ligand 8 |
IFNG | 12q14 | Interferon gamma |
IFNGR1 | 6q23-q24 | Interferon gamma receptor 1 |
IFNGR2 | 21q22.1 | Interferon gamma receptor 2 (interferon gamma transducer 1) |
SOCS1 | 16p13.13 | Suppressor of cytokine signaling 1 |
SOCS2 | 12q | Suppressor of cytokine signaling 2 |
Kinases and phosphatases (n = 5) | ||
AKT1 | 14q32.33 | V-akt murine thymoma viral oncogene homolog 1 |
ULK3 | 15q24.1 | Unc-51 like kinase 3 |
PTPN1 | 20q12.1-q13.2 | Protein tyrosine phosphatase non-receptor type 1 |
PTPN2 | 18p11.3-p11.2 | Protein tyrosine phosphatase non-receptor type 2 |
PTPN22 | 1p13.2 | Protein tyrosine phosphatase non-receptor type 22 |