Skip to main content

Table 1 List and characteristics of the 48 sequenced genes (obtained from GeneCards® database)

From: Novel analytical methods to interpret large sequencing data from small sample sizes

Gene symbol Chromosomal location Gene name
Plasma proteins, membrane transporters, and regulators (n = 10)
 ABCB1 7q21.12 ATP-binding cassette subfamily B member 1
 ABCC2 10q24 ATP-binding cassette subfamily C member 2
 ABCG2 4q22.1 ATP-binding cassette subfamily G member 2 (Junior blood group)
 HFE 6p21.3 Hemochromatosis
 HIF1A 14q23.2 Hypoxia inducible factor 1 alpha subunit
 ORM1 9q32 Orosomucoid 1
 SLC22A1 6q25.3 Solute carrier family 22 member 1
 SLC22A4 5q23.3 Solute carrier family 22 member 4
 SLCO1A2 12p12 Solute carrier organic anion transporter family member 1A2
 SLCO1B1 12p12 Solute carrier organic anion transporter family member 1B1
Metabolism enzymes and regulators (n = 12)
 CYP1A1 15q24.1 Cytochrome P450 family 1 subfamily A member 1
 CYP1A2 15q24.1 Cytochrome P450 family 1 subfamily A member 2
 CYP2C19 10q24 Cytochrome P450 family 2 subfamily C member 19
 CYP2C8 10q24.1 Cytochrome P450 family 2 subfamily C member 8
 CYP2C9 10q24.1 Cytochrome P450 family 2 subfamily C member 9
 CYP2D6 22q13.1 Cytochrome P450 family 2 subfamily D member 6
 CYP3A4 7q21.1 Cytochrome P450 family 3 subfamily A member 4
 CYP3A5 7q21.1 Cytochrome P450 family 3 subfamily A member 5
 NR1I2 3q12-q13.3 Nuclear receptor subfamily 1 group I member 2
 NR1I3 1q23.3 Nuclear receptor subfamily 1 group I member 3
 UGT1A1 2q37.1 UDP glucuronosyltransferase family 1 member A1
 UGT1A9 2q37 UDP glucuronosyltransferase family 1 member A9
Cell cycle and proliferation (n = 5)  
 CCND1 11q13 Cyclin D1
 PPP2R2A 8p21.2 Protein phosphatase 2 regulatory subunit B. alpha
 RPA1 17p13.3 Replication protein A1
 RPA2 1p35 Replication protein A2
 RPA3 7p21.3 Replication protein A3
DNA repair (n = 10)
 ERCC2 19q13.3 Excision repair cross-complementation group 2
 ERCC3 2q21 Excision repair cross-complementation group 3
 ERCC4 16p13.3 Excision repair cross-complementation group 4
 ERCC5 13q22-q34 Excision repair cross-complementation group 5
 ERCC6 10q11 Excision repair cross-complementation group 6
 ERCC8 5q12.1 Excision repair cross-complementation group 8
 LIG1 19q13.33 DNA ligase 1
 RAD23B 9p31.2 RAD23 homolog B. nucleotide excision repair protein
 XPA 9p22.3 Xeroderma pigmentosum complementation group A
 XPC 3p25.1 Xeroderma pigmentosum complementation group C
Cytokine pathways (n = 6)
 CXCL8 4q13-q21 C-X-C motif chemokine ligand 8
 IFNG 12q14 Interferon gamma
 IFNGR1 6q23-q24 Interferon gamma receptor 1
 IFNGR2 21q22.1 Interferon gamma receptor 2 (interferon gamma transducer 1)
 SOCS1 16p13.13 Suppressor of cytokine signaling 1
 SOCS2 12q Suppressor of cytokine signaling 2
Kinases and phosphatases (n = 5)
 AKT1 14q32.33 V-akt murine thymoma viral oncogene homolog 1
 ULK3 15q24.1 Unc-51 like kinase 3
 PTPN1 20q12.1-q13.2 Protein tyrosine phosphatase non-receptor type 1
 PTPN2 18p11.3-p11.2 Protein tyrosine phosphatase non-receptor type 2
 PTPN22 1p13.2 Protein tyrosine phosphatase non-receptor type 22