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Fig. 6 | Human Genomics

Fig. 6

From: lncRNA TUG1 modulates proliferation, apoptosis, invasion, and angiogenesis via targeting miR-29b in trophoblast cells

Fig. 6

miR-29b negative regulates the expression of MCL1, VEGFA, and MMP2 to be involved in TUG1-mediated biological functions. a Comparison of MCL1, VEGFA, and MMP2 level in placenta tissues of healthy pregnancy and pre-eclampsia patients. *P < 0.05 vs. normal. b Correlation analysis of MCL1, VEGFA, and MMP2 expression with miR-29b in placenta tissues of pre-eclampsia patients. c MCL1, VEGFA, and MMP2 expression in HTR-8/SVneo and BeWo cells transfected with miR-29b mimic or inhibitor. *P < 0.05 and **P < 0.01 vs. NC mimic. **P < 0.01 vs. NC inhibitor. d The luciferase activity of the 3′-UTR of MCL1, VEGFA, and MMP2 in miR-29b overexpressing or knocked down HTR-8/SVneo cells. *P < 0.05 and **P < 0.01 vs. NC mimic. *P < 0.05 and **P < 0.01 vs. NC inhibitor. e Protein expression levels of PI3K, AKT, and ERK as well as p-PI3K, p-AKT, and p-ERK. *P < 0.05 and **P < 0.01 vs. control. *P < 0.05 and **P < 0.01 vs. siTUG1+NC mimic. *P < 0.05 and **P < 0.01 vs. siTUG1+NC inhibitor. f Proteins expression levels of MCL1, VEGFA, and MMP2. *P < 0.05 and **P < 0.01 vs. control. *P < 0.05 and **P < 0.01 vs. siTUG1+NC mimic. *P < 0.05 and **P < 0.01 vs. siTUG1+NC inhibitor

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