Table 1 Summary of biological process gene set enrichment analysis

Brown fat cell differentiation

8.3154e−21

PPARG, PIK3R1, MRAP, PPARGC1A, SLC2A4, ADIG, ADIPOQ, ADRB1, PRDM16, ADRB3, CEBPB, FABP4, UCP1

Response to cold

7.84828e−16

PPARG, ACOT11, PMCH, AGT, ADRB1, UCP3, GMPR, ADRB3, TRH, IL6

Positive regulation of transcription from RNA polymerase II promoter

2.90244e−12

NFKB1, PPARG, NFE2L2, TWIST1, SREBF1, PPARA, PIK3R1, LPIN2, ESR1, CTNNB1, HNF4A, IL10, RXRA, EN1, TGFB1, ESRRA, IL6, CREBBP, PPARGC1B

Lipid biosynthetic process

7.45936e−12

SREBF1, DGAT2L6, MOGAT2, DGAT2, PRKAA2, MOGAT3, MOGAT1, AWAT1

Cellular lipid metabolic process

6.70379e−11

CYP7A1, LPIN1, PPARA, DGAT2, PRKAA2, LPIN2, AGT, DGAT1, RXRA, CREBBP, UCP1

Glucose homeostasis

7.26406e−11

PPARG, SLC2A4, PMCH, IRS1, PRKAA2, DBH, HNF4A, ADIPOQ, INS

Response to drug

1.68321e−10

PPARG, FXN, SREBF1, PIK3R1, CTNNB1, HNF4A, IL10, LPL, CYP19A1, TGFB1, NOS3, IL6, LIPE, CFTR

Lipid metabolic process

1.74841e−10

FADS2, PPARG, SREBF1, PPARA, LPIN2, LEP, LPL, UCP3, CIDEA, APOC3, LPIN3, FABP4, LIPE

Triglyceride biosynthetic process

7.84617e−10

LPN1, MOGAT2, DGAT2, LPIN2, LPL, DGAT1, GPAT2

Response to hypoxia

9.5641e−10

PPARA, LEP, NRF1, MMP2, UCP2, UCP3, TRH, TGFB1, ADIPOQ, NOS3, CREBBP

Positive regulation of MAPK cascade

1.16264e−09

LEP, CTNNB1, AGT, IGF1R, CNTF, ADRB3, IL6, INS

Response to insulin stimulus

1.2526e−09

MC4R, RETN, PPARA, IRS1, LEP, IL10, UCP3, IL6

Aging

5.88491e−09

SREBF1, AGT, ADRB1, UCP3, ADRB3, RXRA, TGFB1, NOS3, IL6

Response to estradiol stimulus

1.57804e−09

PIK3R1, ESR1, DBH, NRF1, CTNNB1, CYP19A1, TGFB1, NOS3

Cellular lipid metabolic process

1.62076e−08

PPARG, LPIN1, SLC2A4, IRS1, UCP2, RXRA, ADIPOQ

Response to organic cyclic compound

8.05856e−08

FXN, STC1, DBH, CYP19A1, RXRA, TRH, NOS3, IL6