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Table 1 Summary of biological process gene set enrichment analysis

From: Identification of key candidate genes and molecular pathways in white fat browning: an anti-obesity drug discovery based on computational biology

Progress Genes in query set Total genes in genome Corrected hypergeometric P value Genes
Brown fat cell differentiation 12 26 8.3154e−21 PPARG, PIK3R1, MRAP, PPARGC1A, SLC2A4, ADIG, ADIPOQ, ADRB1, PRDM16, ADRB3, CEBPB, FABP4, UCP1
Response to cold 10 29 7.84828e−16 PPARG, ACOT11, PMCH, AGT, ADRB1, UCP3, GMPR, ADRB3, TRH, IL6
Positive regulation of transcription from RNA polymerase II promoter 20 578 2.90244e−12 NFKB1, PPARG, NFE2L2, TWIST1, SREBF1, PPARA, PIK3R1, LPIN2, ESR1, CTNNB1, HNF4A, IL10, RXRA, EN1, TGFB1, ESRRA, IL6, CREBBP, PPARGC1B
Lipid biosynthetic process 8 29 7.45936e−12 SREBF1, DGAT2L6, MOGAT2, DGAT2, PRKAA2, MOGAT3, MOGAT1, AWAT1
Cellular lipid metabolic process 11 128 6.70379e−11 CYP7A1, LPIN1, PPARA, DGAT2, PRKAA2, LPIN2, AGT, DGAT1, RXRA, CREBBP, UCP1
Glucose homeostasis 9 64 7.26406e−11 PPARG, SLC2A4, PMCH, IRS1, PRKAA2, DBH, HNF4A, ADIPOQ, INS
Response to drug 14 301 1.68321e−10 PPARG, FXN, SREBF1, PIK3R1, CTNNB1, HNF4A, IL10, LPL, CYP19A1, TGFB1, NOS3, IL6, LIPE, CFTR
Lipid metabolic process 13 241 1.74841e−10 FADS2, PPARG, SREBF1, PPARA, LPIN2, LEP, LPL, UCP3, CIDEA, APOC3, LPIN3, FABP4, LIPE
Triglyceride biosynthetic process 7 33 7.84617e−10 LPN1, MOGAT2, DGAT2, LPIN2, LPL, DGAT1, GPAT2
Response to hypoxia 11 175 9.5641e−10 PPARA, LEP, NRF1, MMP2, UCP2, UCP3, TRH, TGFB1, ADIPOQ, NOS3, CREBBP
Positive regulation of MAPK cascade 8 61 1.16264e−09 LEP, CTNNB1, AGT, IGF1R, CNTF, ADRB3, IL6, INS
Response to insulin stimulus 8 62 1.2526e−09 MC4R, RETN, PPARA, IRS1, LEP, IL10, UCP3, IL6
Aging 9 114 5.88491e−09 SREBF1, AGT, ADRB1, UCP3, ADRB3, RXRA, TGFB1, NOS3, IL6
Response to estradiol stimulus 8 89 1.57804e−09 PIK3R1, ESR1, DBH, NRF1, CTNNB1, CYP19A1, TGFB1, NOS3
Cellular lipid metabolic process 7 56 1.62076e−08 PPARG, LPIN1, SLC2A4, IRS1, UCP2, RXRA, ADIPOQ
Response to organic cyclic compound 8 112 8.05856e−08 FXN, STC1, DBH, CYP19A1, RXRA, TRH, NOS3, IL6
  1. Among the most significantly enriched biological processes above the cutoff, those most relevant to brown-fat-like development based on the available literature and research were selected. The analysis of enriched biological process annotations resulted in 16 sets of annotations containing 70 genes