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Table 4 The association of the rs2151280 with lung cancer risks and NSCLC in female and male population

From: Association between polymorphism in CDKN2B-AS1 gene and its interaction with smoking on the risk of lung cancer in a Chinese population

Genotyping

Lung cancer

 

Non-small-cell lung cancer

 
 

Controls (%)

Cases (%)

OR (95%CI)

P value

ORª (95%CI)

Pª value

Cases (%)

OR (95%CI)

P value

ORª (95%CI)

Pª value

Female

           

TT

104 (37.1)

102 (40.5)

1.00 (ref)

   

73 (37.8)

1.00 (ref)

   

TC

123 (43.9)

122 (48.4)

1.011 (0.698–1.465)

0.953

0.984 (0.676–1.434)

0.935

97 (50.3)

1.124 (0.753–1.677)

0.569

1.109 (0.740–1.661)

0.616

CC

53 (18.9)

28 (11.1)

0.539 (0.316–0.918)

0.023

0.533 (0.310–0.916)

0.023

23 (11.9)

0.618 (0.348–1.097)

0.100

0.606 (0.339–1.081)

0.090

CC+TC vs TT

 

0.869 (0.613–1.232)

0.431

0.850 (0.596–1.211)

0.368

 

0.971 (0.665–1.419)

0.880

0.957 (0.653–1.402)

0.822

CC vs TC+TT

 

0.535 (0.327–0.877)

0.013

0.538 (0.326–0.888)

0.015

 

0.579 (0.342–0.983)

0.043

0.572 (0.335–0.975)

0.040

T allele

331 (59.1)

326 (64.7)

1.00 (ref)

   

243 (63.0)

1.00 (ref)

   

C allele

229 (40.9)

178 (35.3)

0.789 (0.616–1.012)

0.062

  

143 (37.0)

0.851 (0.652–1.110)

0.234

  

Male

           

TT

99 (37.8)

105 (41.2)

1.00 (ref)

    

1.00 (ref)

   

TC

132 (50.4)

122 (47.8)

0.871 (0.603–1.260)

0.464

0.929 (0.570–1.515)

0.769

80 (40.0)

0.928 (0.626–1.375)

0.710

1.078 (0.624–1.862)

0.788

CC

31 (11.8)

28 (11.0)

0.852 (0.477–1.521)

0.587

0.724 (0.336–1.558)

0.408

99 (49.5)

0.838 (0.448–1.570)

0.582

0.743 (0.315–1.752)

0.497

CC+TC vs TT

 

0.868 (0.610–1.235)

0.431

0.886 (0.555–1.4130)

0.611

21 (10.5)

0.911 (0.625–1.329)

0.628

1.004 (0.596–1.692)

0.989

CC vs TC+TT

 

0.919 (0.534–1.582)

0.761

0.753 (0.367–1.545)

0.440

 

0.874 (0.486–1.573)

0.654

0.713 (0.320–1.590)

0.408

T allele

330 (63.0)

332 (65.1)

1.00 (ref)

   

259 (64.8)

1.00 (ref)

   

C allele

194 (37.0)

178 (34.9)

0.912 (0.707–1.176)

0.477

  

141 (35.2)

0.926 (0.706–1.214)

0.579

  
  1. OR odds ratio, CI confidence interval, NSCLC non-small-cell lung cancer
  2. aAdjusted for age, gender, and smoking