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Table 5 Stratified analyses of the rs2151280 with lung cancer risk and NSCLC by age

From: Association between polymorphism in CDKN2B-AS1 gene and its interaction with smoking on the risk of lung cancer in a Chinese population

Genotyping

Lung cancer

 

Non-small-cell lung cancer

 
 

Controls (%)

Cases (%)

OR (95%CI)

P value

ORª (95%CI)

Pª value

Cases (%)

OR (95%CI)

P value

ORª (95%CI)

Pª value

> 60

           

TT

95 (36.8)

106 (40.9)

1.00 (ref)

   

83 (38.1)

1.00 (ref)

   

TC

117 (45.3)

123 (47.5)

0.942 (0.647–1.371)

0.756

0.922 (0.617–1.380)

0.695

110 (50.5)

1.076 (0.726–1.594)

0.715

1.054 (0.690–1.611)

0.807

CC

46 (17.8)

30 (11.6)

0.584 (0.324–1.000)

0.050

0.622 (0.350–1.108)

0.107

25 (11.5)

0.622 (0.352–1.099)

0.102

0.660 (0.358–1.218)

0.184

CC+TC vs TT

 

0.841 (0.590–1.199)

0.339

0.840 (0.574–1.229)

0.369

 

0.948 (0.653–1.376)

0.779

0.946 (0.633–1.414)

0.786

CC vs TC+TT

 

0.604 (0.368-0.992)

0.046

0.65 (0.381–1.109)

0.114

 

0.597 (0.353–1.009)

0.054

0.641 (0.365–1.128)

0.123

T allele

307 (59.5)

335 (64.7)

1.00 (ref)

   

276 (63.3)

1.00 (ref)

   

C allele

209 (40.5)

183 (35.3)

0.802 (0.624–1.032)

0.086

  

160 (36.7)

0.852 (0.655–1.107)

0.230

  

≤ 60

           

TT

108 (38.0)

101 (40.7)

1.00 (ref)

   

70 (40.0)

1.00 (ref)

   

TC

138 (48.6)

121 (48.8)

0.938 (0.651–1.351)

0.729

1.079 (0.717–1.622)

0.716

86 (49.1)

0.961 (0.642–1.440)

0.849

1.151 (0.730–1.815)

0.544

CC

38 (13.4)

26 (10.5)

0.732 (0.415–1.291)

0.281

0.660 (0.353–1.234)

0.193

19 (10.9)

0.771 (0.412–1.445)

0.418

0.763 (0.383–1.521)

0.443

CC+TC vs TT

 

0.893 (0.630–1.266)

0.525

0.976 (0.662–1.439)

0.904

 

0.920 (0.626–1.354)

0.674

1.056 (0.685–1.628)

0.805

CC vs TC+TT

 

0.758 (0.446–1.289)

0.307

0.633 (0.353–1.136)

0.125

 

0.788 (0.439–1.417)

0.427

0.707 (0.372–1.342)

0.288

T allele

354 (62.3)

323 (65.1)

1.00 (ref)

   

226 (64.6)

1.00 (ref)

   

C allele

214 (37.7)

173 (34.9)

0.886 (0.689–1.139)

0.344

  

124 (35.4)

0.908 (0.688–1.197)

0.493

  
  1. OR odds ratio, CI confidence interval, NSCLC non-small-cell lung cancer
  2. aAdjusted for age, gender, and smoking
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Human Genomics

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