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Table 1 The risk of 5-year mortality by 8q24.3 copy number alteration—categorized by anatomical location of each cancer—and expressed as odds ratios [OR] and 95% confidence intervals [CI]

From: Copy number of 8q24.3 drives HSF1 expression and patient outcome in cancer: an individual patient data meta-analysis

 TotalModel 1*(n = 9568)Model 2** (n = 7593)Model 3*** (n = 4110)
% died% diploidnDeletions (− 1 or − 2)Gain (+ 1)Amplification (≥ + 2)Deletions (− 1 or − 2)Gain (+ 1)Amplification (≥ + 2)Deletions (− 1 or − 2)Gain (+ 1)Amplification (≥ + 2)
Adrenal glands1.879.8109 8.60 [0.5–148.39]       
Bladder44.839.187 0.75 [0.31–1.84]       
Blood56.383.2238 0.87 [0.42–1.80]       
Brain51.480.21,021.65 [0.94–2.90]0.84 [0.56–1.24]0.27 [0.12–0.60]1.23 [0.79–1.92]0.83 [0.43–1.59]0.68 [0.37–1.25]   
Breast18.656.012721.17 [0.55–2.50]1.05 [0.72–1.52]1.31 [0.92–1.86]      
Cervical19.952.52760.78 [0.21–2.88]1.25 [0.68–2.32]       
Colorectal18.938.05133.64 [1.31–10.17]1.51 [0.93–2.46]0.90 [0.25–3.25]4.12 [1.15–14.82]1.75 [1.32–2.31]0.78 [0.23–2.64]   
Esophagus38.425.21591.16 [0.32–4.23]1.32 [0.60–2.88]0.93 [0.32–2.70]      
Eyes26.724.075 9.38 [1.14–77.14]5.67 [0.51–62.66]      
Head and neck39.127.8468 1.35 [0.88–2.09]2.23 [1.10–4.51] 1.40 [0.75–2.62]2.68 [2.17–3.30]   
Kidney23.077.67380.49 [0.22–1.11]1.83 [1.17–2.87] 0.41 [0.21–0.82]1.70 [0.73–3.96] 0.52 [0.31–0.85]0.60 [0.23–1.62] 
Liver32.631.93131.49 [0.52–4.26]0.90 [0.52–1.57]1.31 [0.66–2.61]      
Lung33.732.88111.49 [0.76–2.90]1.70 [1.22–2.36]0.76 [0.37–1.56]1.97 [1.02–3.80]1.76 [1.24–2.51]0.80 [0.44–1.46]1.24 [0.34–4.51]1.77 [1.06–2.97]0.40 [0.10–1.65]
Mesenchyme33.555.11851.47 [0.60–3.56]1.91 [0.94–3.89]       
Mesothelium81.373.375 1.08 [0.26–4.48]       
Ovarian47.516.15031.81 [0.83–3.94]1.35 [0.81–2.27]1.01 [0.60–1.72]1.83 [1.39–2.41]1.53 [1.15–2.05]1.33 [0.91–1.93]1.52 [1.26–1.83]7.24 [6.44–8.13]9.73 [7.19–13.16]
Pancreas55.860.4154 1.87 [0.88–4.01]1.69 [0.53–5.42]      
Prostate0.957.76475.61 [0.56–56.12]0.68 [0.07–6.56]1.84 [0.19–17.96]24.75 [0.8–765]1.12 [0.76–1.64]4.41 [3.41–5.71]   
Skin31.642.13351.22 [0.48–3.11]0.91 [0.56–1.50]1.22 [0.48–3.11]      
Stomach36.334.83970.91 [0.33–2.53]0.60 [0.39–0.93]0.70 [0.26–1.86]0.93 [0.13–6.52]0.60 [0.37–0.98]0.56 [0.36–0.87]   
Testicle1.619.2125         
Thymus5.389.4113         
Thyroid2.497.4464         
Uterus18.160.74914.31 [1.70–10.88]3.53 [2.11–5.90]4.31 [1.62–11.48]4.84 [2.75–8.51]3.67 [2.03–6.66]4.58 [1.43–14.6]1.13 [0.16–7.78]1.99 [1.28–3.08]2.08 [0.06–75.09]
Total28.354.195681.42 [1.16–1.73]1.31 [1.19–1.45]1.20 [1.02–1.40]1.37 [0.88–2.15]1.31 [0.78–2.20]1.41 [0.76–2.61]1.23 [0.69–2.16]1.98 [1.22–3.21]2.19 [1.13–4.26]
  1. *Model 1 is unadjusted for any confounders
  2. **Model 2 is adjusted for age, sex, calendar period, and clustering by study
  3. ***Model 3 is additionally adjusted for interaction with tumor stage and confounding by HSF1