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Table 2 Hazard ratios (HR) of overall survival using Cox regression models

From: Common polymorphic inversions at 17q21.31 and 8p23.1 associate with cancer prognosis

Tumor

inv8p23.1

inv17q21.31

Std-Std

Std-Inv

Inv-Inv

p value

Std-Std

Std-Inv

Inv-Inv

p value

Lung1

1.10 (0.80-1.50)

0.55

0.78 (0.55-1.12)

0.18

Lung2

1

1

0.96 (0.65–1.42)

0.84

1

1

0.72 (0.35–1.47)

0.37

Liver

1

1

0.84 (0.45–1.55)

0.58

1

0.74 (0.42-1.30)

1

0.30

Colorectal

1

0.68 (0.38–1.19)

1

0.18

1

0.74 (0.40-1.36)

1

0.33

Stomach

1

1

0.42 (0.18–0.93)

3.3 × 10−2

1

2.19 (1.20–3.99)

2.19 (1.20–3.99)

1.1 × 10−2

Breast

1

1

2.00 (1.27–3.16)

2.6 × 10−3

1.34 (0.93–1.94)

0.12

  1. The results are shown for the best genetic model for each inversion in each tumor. Associations in italics were nominally significant (p value < 0.05). In the additive model, HR corresponds to each inverted allele. For the other models, HR was computed using Std-Std as reference
  2. Lung1 LUAD (lung adenocarcinoma), Lung2 LUSC (lung squamous cell carcinoma), Liver LIHC (liver hepatocellular carcinoma), Colorectal COAD + READ (colon adenocarcinoma), Stomach STAD (stomach adenocarcinoma), Breast BRCA (breast invasive carcinoma)
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Human Genomics

ISSN: 1479-7364