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Table 3 Crude Cox regression models between chromosomal inversions and disease-free survival

From: Common polymorphic inversions at 17q21.31 and 8p23.1 associate with cancer prognosis

Tumor

inv8p23.1

inv17q21.31

Std-Std

Std-Inv

Inv-Inv

p value

Std-Std

Std-Inv

Inv-Inv

p value

Lung1

0.78 (0.61–1)

0.05

0.88 (0.67–1.16)

0.37

Lung2

1

0.82 (0.52–1.28)

0.82 (0.52–1.28)

0.38

1

1

0.49 (0.2–1.2)

0.12

Liver

1

1

1.01 (0.61–1.68)

0.96

1

1.13 (0.74–1.74)

1.13 (0.74–1.74)

0.57

Colorectal

1

0.86 (0.51–1.44)

0.86 (0.51–1.44)

0.56

1

1.67 (1.1–2.53)

1

1.57 × 10−2

Stomach

1

1

0.79 (0.44–1.4)

0.42

1

0.98 (0.57–1.68)

1

0.93

Breast

1

0.66 (0.41–1.04)

1

0.08

1

1

2.01 (0.81–4.99)

0.13

  1. The results are for the best genetic model for each inversion in each tumor. Associations in italics were nominally significant (p value < 0.05). In the additive model, HR corresponds to each inverted allele. For the other models, HR was computed using Std-Std as the reference
  2. Lung1 LUAD (lung adenocarcinoma), Lung2 LUSC (lung squamous cell carcinoma), Liver LIHC (liver hepatocellular carcinoma), Colorectal COAD + READ (colon adenocarcinoma), stomach: STAD (stomach adenocarcinoma), Breast BRCA (breast invasive carcinoma)