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Table 2 Predicted binding sites for transcription factors and promoter activity affected by DSVs and SNPs

From: Genetic variants of VEGFR-1 gene promoter in acute myocardial infarction

DSVs/SNPs

Binding cites for transcription factors

Promoter activity

AMI/CTR

Creating

Abolishing

g.28495805C>T (rs111458691)

ELF5, NFE2L1:MafG

EGR2

AMI

g.28495796G>T

ESRRA, NR2C2, PAX5, PPARG::RXRA, ZEB1

No change

AMI

g.28495678G>A

NFATC1

TFE3

No change

CTR

g.28495445G>T

FOXO3, NFE2L1::MafG

NFKB1

AMI

g.28495356G>A

HINFP

E2F4, TFAP2C

No change

CTR

g.28495341A>G

EGR1, NRF1

BRCA1, HIF1A::ARNT

No change

AMI

g.28495138G>C

NHLH1, HIF1A::ARNT

AMI

g.28494900G>A

NF1C

AMI