Table 2 Predicted binding sites for transcription factors and promoter activity affected by DSVs and SNPs
From: Genetic variants of VEGFR-1 gene promoter in acute myocardial infarction
DSVs/SNPs | Binding cites for transcription factors | Promoter activity | AMI/CTR | |
|---|---|---|---|---|
Creating | Abolishing | |||
g.28495805C>T (rs111458691) | ELF5, NFE2L1:MafG | EGR2 | ↑ | AMI |
g.28495796G>T | – | ESRRA, NR2C2, PAX5, PPARG::RXRA, ZEB1 | No change | AMI |
g.28495678G>A | NFATC1 | TFE3 | No change | CTR |
g.28495445G>T | FOXO3, NFE2L1::MafG | NFKB1 | ↓ | AMI |
g.28495356G>A | HINFP | E2F4, TFAP2C | No change | CTR |
g.28495341A>G | EGR1, NRF1 | BRCA1, HIF1A::ARNT | No change | AMI |
g.28495138G>C | – | NHLH1, HIF1A::ARNT | ↓ | AMI |
g.28494900G>A | NF1C | – | ↑ | AMI |