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Table 2 Predicted binding sites for transcription factors and promoter activity affected by DSVs and SNPs

From: Genetic variants of VEGFR-1 gene promoter in acute myocardial infarction

DSVs/SNPs Binding cites for transcription factors Promoter activity AMI/CTR
Creating Abolishing
g.28495805C>T (rs111458691) ELF5, NFE2L1:MafG EGR2 AMI
g.28495796G>T ESRRA, NR2C2, PAX5, PPARG::RXRA, ZEB1 No change AMI
g.28495678G>A NFATC1 TFE3 No change CTR
g.28495445G>T FOXO3, NFE2L1::MafG NFKB1 AMI
g.28495356G>A HINFP E2F4, TFAP2C No change CTR
g.28495341A>G EGR1, NRF1 BRCA1, HIF1A::ARNT No change AMI
g.28495138G>C NHLH1, HIF1A::ARNT AMI
g.28494900G>A NF1C AMI