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Table 2 Comparison of genotype frequencies of miRNA polymorphisms between patients and controls

From: Associations between microRNA (miR-25, miR-32, miR-125, and miR-222) polymorphisms and recurrent implantation failure in Korean women

Genotypes Controls
(n = 228)
IF ≥ 2
(n = 118)
AOR (95% CI)a Pa IF ≥ 3 (n = 106) AOR (95% CI)a Pa IF ≥ 4 (n = 75) AOR (95% CI)a Pa
miR-25 rs1527423 T>C
 TT 179 (78.5) 94 (79.7) 1.000 (reference)   84 (79.25) 1.000 (reference)   57 (76.00) 1.000 (reference)  
 TC 46 (20.2) 23 (19.5) 0.947 (0.541–1.658) 0.849 21 (19.81) 0.968 (0.542–1.728) 0.913 17 (22.67) 1.146 (0.608–2.159) 0.673
 CC 3 (1.3) 1 (0.8) 0.632 (0.065–6.169) 0.693 1 (0.94) 0.709 (0.073–6.931) 0.767 1 (1.33) 1.044 (0.106–10.249) 0.971
 Dominant (TT vs TC+CC)    0.927 (0.535–1.606) 0.788   0.952 (0.540–1.679) 0.865   1.139 (0.613–2.116) 0.680
 Recessive (TT+TC vs CC)    0.639 (0.066–6.218) 0.700   0.713 (0.073–6.959) 0.771   1.014 (0.104–9.927) 0.991
 HWE P 0.981 0.753    0.804    0.832   
miR-32 rs7041716 C>A
 CC 187 (82.0) 94 (79.7) 1.000 (reference)   85 (80.19) 1.000 (reference)   58 (77.33) 1.000 (reference)  
 CA 39 (17.1) 22 (18.6) 1.123 (0.629–2.004) 0.695 19 (17.92) 1.069 (0.582–1.963) 0.829 16 (21.33) 1.315 (0.683–2.530) 0.413
 AA 2 (0.9) 2 (1.7) 1.893 (0.262–13.686) 0.527 2 (1.89) 2.072 (0.286–15.003) 0.471 1 (1.33) 1.446 (0.128–16.310) 0.766
 Dominant (CC vs CA+AA)    1.163 (0.663–2.040) 0.600   1.121 (0.623–2.016) 0.704   1.322 (0.697–2.508) 0.392
 Recessive (CC+CA vs AA)    1.876 (0.260–13.511) 0.532   2.064 (0.286–14.894) 0.472   1.390 (0.124–15.610) 0.790
 HWE P 0.983 0.594    0.45    0.906   
miR-125a rs12976445 C>T
 CC 170 (74.6) 98 (83.1) 1.000 (reference)   87 (82.08) 1.000 (reference)   63 (84.00) 1.000 (reference)  
 CT 52 (22.8) 20 (16.9) 0.680 (0.383–1.208) 0.188 19 (17.92) 0.734 (0.408–1.321) 0.303 12 (16.00) 0.633 (0.316–1.266) 0.196
 TT 6 (2.6) 0 (0.0) N/A 0.995 0 (0.00) 0.000 (0.000–0.000) 0.995 0 (0.00) 0.000 (0.000–0.000) 0.993
 Dominant (CC vs CT+TT)    0.610 (0.346–1.075) 0.087   0.658 (0.368–1.177) 0.158   0.568 (0.286–1.130) 0.107
 Recessive (CC+CT vs TT)    N/A 0.995   N/A 0.995   N/A 0.993
 HWE P 0.408 0.315    0.311    0.448   
miR-222 rs34678647 G>T
 GG 133 (58.3) 62 (52.5) 1.000 (reference)   56 (52.83) 1.000 (reference)   39 (52.00) 1.000 (reference)  
 GT 79 (34.6) 48 (40.7) 1.320 (0.825–2.112) 0.247 42 (39.62) 1.284 (0.787–2.096) 0.317 31 (41.33) 1.343 (0.775–2.327) 0.294
 TT 16 (7.0) 8 (6.8) 1.030 (0.415–2.560) 0.949 8 (7.55) 1.144 (0.457–2.859) 0.774 5 (6.67) 0.999 (0.340–2.938) 0.999
 Dominant (GG vs GT+TT)    1.273 (0.813–1.993) 0.291   1.262 (0.792–2.009) 0.327   1.288 (0.761–2.179) 0.346
 Recessive (GG+GT vs TT)    0.944 (0.391–2.279) 0.898   1.054 (0.435–2.553) 0.908   0.911 (0.321–2.589) 0.861
 HWE P 0.371 0.752    0.974    0.726   
  1. IF, implantation failure; AOR, adjusted odds ratio; for AOR, OR adjusted by age of participants; 95% CI, 95% confidence interval; N/A, not applicable
  2. aAdjusted by age