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Table 3 Allele combination analysis for the miRNA polymorphisms in patients and controls using MDR

From: Associations between microRNA (miR-25, miR-32, miR-125, and miR-222) polymorphisms and recurrent implantation failure in Korean women

Allele combinations Overall
(2n = 692)
Controls
(2n = 456)
RIF
(2n = 236)
OR (95% CI) Pa
miR-25 T>C/ miR-32 C>A/ miR-125aC>T/ miR-222G>T
 T-C-C-G 0.5035 0.5203 0.4841 1.000 (reference)  
 T-C-C-T 0.2081 0.1798 0.2482 1.496 (1.000–2.237) 0.049
 T-C-T-G 0.0884 0.1026 0.0566 0.575 (0.299–1.106) 0.094
 T-C-T-T 0.0047 0.0059 0.0065 1.386 (0.228–8.414) 0.662
 T-A-C-G 0.0563 0.0436 0.0797 1.975 (1.014–3.847) 0.042
 C-C-C-G 0.0653 0.0527 0.0753 1.559 (0.813–2.989) 0.178
 C-C-C-T 0.0124 0.0260 0.0000 0.083 (0.005–1.415) 0.022
 C-C-T-G 0.0136 0.0140 0.0191 1.732 (0.518–5.798) 0.352
miR-25 T>C/ miR-125aC>T/ miR-222G>T
 T-C-G 0.5598 0.5617 0.5635 1.000 (reference)  
 T-C-T 0.2253 0.2013 0.2650 1.318 (0.899–1.933) 0.157
 T-T-G 0.0949 0.1120 0.0594 0.528 (0.282–0.990) 0.044
 T-T-T 0.0087 0.0110 0.0062 0.385 (0.045–3.331) 0.668
 C-C-G 0.0783 0.0691 0.0868 1.203 (0.662–2.185) 0.543
 C-C-T 0.0152 0.0276 0.0000 0.071 (0.004–1.207) 0.006
 C-T-G 0.0141 0.0138 0.0191 1.604 (0.481–5.355) 0.523
 C-T-T 0.0037 0.0036 0.0000 0.384 (0.018–8.068) 0.550
miR-25 T>C/ miR-32 C>A/ miR-222 G>T
 T-C-G 0.5909 0.6224 0.5405 1.000 (reference)  
 T-C-T 0.2128 0.1841 0.2554 1.585 (1.071–2.345) 0.021
 T-A-G 0.0643 0.0538 0.0824 1.686 (0.896–3.173) 0.102
 T-A-T 0.0207 0.0256 0.0158 0.740 (0.234–2.338) 0.785
 C-C-G 0.0788 0.0665 0.0940 1.627 (0.903–2.931) 0.103
 C-C-T 0.0178 0.0327 0.0000 0.071 (0.004–1.204) 0.007
 C-A-G 0.0131 0.0139 0.0119 1.109 (0.273–4.507) 1.000
 C-A-T 0.0016 0.0010 0.0000 N/A N/A
miR-25  T>C/ miR-222G>T
 T-G 0.6545 0.6739 0.6229 1.000 (reference)  
 T-T 0.2342 0.2121 0.2712 1.378 (0.950–1.999) 0.090
 C-G 0.0926 0.0827 0.1059 1.374 (0.799–2.362) 0.249
 C-T 0.0187 0.0313 0.0000 0.072 (0.004–1.214) 0.007
miR-25 T>C/ miR-125aC>T
 T-C 0.7844 0.7625 0.8277 1.000 (reference)  
 T-T 0.1043 0.1235 0.0663 0.510 (0.285–0.913) 0.022
 C-C 0.0942 0.0972 0.0875 0.852 (0.492–1.474) 0.566
 C-T 0.0170 0.0169 0.0184 0.892 (0.265–3.002) 1.000
  1. Italicized text indicates significant P values
  2. RIF, recurrent implantation failure; OR, odds ratio; 95% CI, 95% confidence interval; N/A, not applicable; MDR, multi-dimensional reduction
  3. aFisher’s exact test