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Table 5 Differences in various clinical parameters according to micro RNA polymorphisms in control women

From: Associations between microRNA (miR-25, miR-32, miR-125, and miR-222) polymorphisms and recurrent implantation failure in Korean women

Control
Genotypes Age (years) BMI (kg/m2) Live births (n) Mean gestational age (weeks) PT (s) aPTT (s) PLT (103/μl) Folate (mg/ml) Total cholesterol (mg/dl) BUN (mg/dl) Creatinine (mg/dl) E2 (Basal) FSH (mU/L) LH (mU/L)
Mean ± SD (228) Mean ± SD (104) Mean ± SD (74) Mean ± SD (96) Mean ± SD (47) Mean ± SD (77) Mean ± SD (187) Mean ± SD (14) Mean ± SD (9) Mean ± SD (30) Mean ± SD (30) Mean ± SD (109) Mean ± SD (109) Mean ± SD (106)
miR-25 T>C
 TT 33.8 ± 3.30 21.7 ± 3.41 1.7 ± 0.62 39.1 ± 1.75 11.7 ± 3.62 30.9 ± 4.76 243.8 ± 59.58 16.1 ± 10.79 188.4 ± 40.62 8.0 ± 1.74 0.7 ± 0.09 27.0 ± 15.02 8.1 ± 2.89 3.1 ± 1.55
 TC 33.8 ± 3.20 22.0 ± 2.91 2.0 ± 0.37 39.4 ± 1.47 10.4 ± 0.98 30.5 ± 4.31 238.0 ± 60.87 13.1 ± 4.61 373.0 ± 52.33 8.1 ± 2.34 0.7 ± 0.05 24.0 ± 14.38 8.5 ± 2.90 4.0 ± 2.17
 CC 33.3 ± 2.52 N/A N/A N/A N/A N/A 297.7 ± 57.76 N/A N/A N/A N/A 22.2 ± 7.87 7.2 ± 1.26 5.6 ± 1.17
 P value 0.974 0.707 0.077 0.465 0.208 0.739 0.246 0.563 0.001 0.915 0.316 0.608 0.681 0.006
miR-32 C>A
 CC 33.7 ± 3.28 21.7 ± 3.33 1.8 ± 0.56 39.5 ± 1.54 11.4 ± 3.24 30.9 ± 4.60 242.0 ± 61.76 15.1 ± 9.34 235.9 ± 102.77 8.3 ± 1.79 0.7 ± 0.07 27.0 ± 14.82 8.0 ± 2.72 3.2 ± 1.67
 CA 33.9 ± 3.30 22.0 ± 3.34 1.9 ± 0.70 37.8 ± 1.86 10.1 ± 1.84 29.3 ± 4.75 249.8 ± 51.16 14.9 207.0 ± 31.11 6.9 ± 1.66 0.7 ± 0.10 24.0 ± 14.35 8.9 ± 3.34 3.8 ± 2.11
 AA 35.0 22.9 1.0 39.5 ± 0.71 11.4 35.7 250.5 ± 67.18 N/A N/A N/A N/A 11.1 5.7 4.1
 P value 0.809 0.882 0.310 0.002 0.720 0.341 0.796 0.987 0.718 0.092 0.316 0.430 0.291 0.296
miR-125a C>T
 CC 33.8 ± 3.39 21.7 ± 3.19 1.8 ± 0.61 39.2 ± 1.75 11.5 ± 3.59 30.5 ± 4.09 240.8 ± 60.91 15.1 ± 9.91 238.2 ± 86.80 7.8 ± 1.84 0.7 ± 0.09 26.5 ± 14.86 8.0 ± 2.43 3.3 ± 1.78
 CT 33.6 ± 2.83 21.4 ± 3.70 1.6 ± 0.51 39.2 ± 1.52 10.9 ± 0.56 31.5 ± 6.91 247.1 ± 58.14 15.0 ± 5.62 212.0 ± 115.31 9.3 ± 1.33 0.7 ± 0.04 25.0 ± 14.57 8.5 ± 3.83 3.4 ± 1.78
 TT 33.3 ± 3.61 23.7 ± 4.04 1.8 ± 0.50 38.3 ± 0.87 10.4 ± 0.76 32.2 ± 0.67 276.5 ± 45.14 0.0 N/A N/A N/A 37.5 ± 12.09 8.0 ± 2.97 2.0 ± 0.42
 P value 0.863 0.460 0.573 0.525 0.791 0.673 0.330 0.988 0.711 0.098 < 0.001 0.506 0.755 0.554
miR-222 G>T
 GG 33.6 ± 3.17 21.5 ± 3.24 1.7 ± 0.58 39.0 ± 1.45 11.0 ± 1.90 31.2 ± 5.25 243.5 ± 58.97 17.1 ± 11.22 177.4 ± 44.07 8.4 ± 1.65 0.7 ± 0.06 25.6 ± 14.52 8.0 ± 2.38 3.4 ± 1.54
 GT 33.9 ± 3.40 22.0 ± 3.47 1.8 ± 0.61 39.5 ± 1.74 10.8 ± 0.72 29.8 ± 3.38 240.9 ± 62.74 12.3 ± 4.13 294.5 ± 95.55 7.8 ± 1.80 0.6 ± 0.08 28.1 ± 15.28 8.4 ± 3.54 3.2 ± 2.08
 TT 34.4 ± 3.44 22.0 ± 3.53 2.2 ± 0.45 38.9 ± 2.93 16.5 ± 11.14 31.1 ± 2.72 254.2 ± 56.51 N/A N/A 4.2 0.6 22.6 ± 13.98 7.9 ± 2.55 3.3 ± 1.76
 P value 0.541 0.778 0.227 0.144 0.946 0.479 0.751 0.561 0.050 0.059 0.005 0.531 0.778 0.845
  1. Italicized text indicates significant P values
  2. BMI, body mass index; PT, prothrombin time; aPTT, activated partial thromboplastin time; PLT, platelets; BUN, blood urea nitrogen; E2, estradiol; TSH, thyroid stimulating hormone; FSH, follicle stimulating hormone; LH, luteinizing hormone; WBC, white blood cell; Hgb, hemoglobin
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Human Genomics

ISSN: 1479-7364