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Table 6 Differences in various clinical parameters according to micro RNA polymorphisms in women with RIF

From: Associations between microRNA (miR-25, miR-32, miR-125, and miR-222) polymorphisms and recurrent implantation failure in Korean women

Patients
Genotypes Age (years) BMI (kg/m2) Previous implantation failure (n) PT (s) aPTT (s) PLT (103/μl) Homocysteine (μmol/L) Folate (mg/ml) Total cholesterol (mg/dl) Uric acid (mg/dl) BUN (mg/dl) Creatinine (mg/dl)
Mean ± SD (118) Mean ± SD (117) Mean ± SD (112) Mean ± SD (110) Mean ± SD (110) Mean ± SD (113) Mean ± SD (35) Mean ± SD (46) Mean ± SD (47) Mean ± SD (58) Mean ± SD (108) Mean ± SD (108)
miR-25 T>C
 TT 34.0 ± 3.27 21.0 ± 2.96 1.1 ± 1.55 11.1 ± 1.64 29.3 ± 3.53 230.7 ± 53.46 6.6 ± 1.41 16.1 ± 12.50 192.2 ± 48.12 3.9 ± 1.02 10.1 ± 2.95 0.8 ± 0.09
 TC 34.5 ± 3.04 21.3 ± 1.78 0.9 ± 1.18 11.3 ± 0.55 28.6 ± 2.93 243.3 ± 75.15 6.4 ± 0.91 13.9 ± 4.13 177.5 ± 23.97 4.0 ± 0.74 11.2 ± 2.16 0.8 ± 0.12
 CC 36.0 20.5 2.0 11.6 31.4 319.0 4.9 12.8 157.0 3.3 10.3 0.8
P value 0.716 0.842 0.700 0.829 0.546 0.268 0.436 0.889 0.322 0.735 0.289 0.319
miR-32C>A
 CC 34.2 ± 3.14 20.9 ± 2.69 1.2 ± 1.48 11.2 ± 1.24 29.4 ± 3.58 228.5 ± 57.00 6.5 ± 1.30 16.9 ± 11.66 188.3 ± 45.71 3.9 ± 0.99 10.2 ± 2.80 0.8 ± 0.10
 CA 33.8 ± 3.61 21.3 ± 3.02 0.9 ± 1.49 10.6 ± 2.32 28.5 ± 2.50 251.4 ± 58.53 6.8 ± 1.65 9.3 ± 6.84 192.7 ± 43.39 3.8 ± 0.83 11.4 ± 2.81 0.8 ± 0.09
 AA 35.0 ± 2.83 22.8 ± 4.45 0.000 10.5 ± 0.50 26.9 ± 2.97 317.0 ± 59.40 N/A N/A 186.5 ± 4.95 0.000 8.0 ± 1.41 0.8 ± 0.07
P value 0.789 0.571 0.412 0.167 0.364 0.037 0.600 0.133 0.927 0.562 0.111 0.600
miR-125aC>T
 CC 34.4 ± 3.00 21.1 ± 2.69 1.0 ± 1.42 11.0 ± 1.60 28.9 ± 3.24 235.8 ± 55.54 6.5 ± 1.08 17.2 ± 12.31 188.7 ± 42.73 3.9 ± 0.94 10.2 ± 2.61 0.8 ± 0.09
 CT 33.0 ± 3.94 20.7 ± 3.12 1.7 ± 1.69 11.4 ± 0.53 30.7 ± 3.97 223.8 ± 73.14 6.6 ± 2.10 10.3 ± 3.87 191.5 ± 56.72 4.2 ± 1.04 10.9 ± 3.81 0.8 ± 0.12
 TT N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
P value 0.068 0.549 0.058 0.308 0.049 0.427 0.829 0.134 0.819 0.302 0.340 0.653
miR-222G>T
 GG 34.8 ± 3.39 21.5 ± 3.09 1.3 ± 1.82 11.1 ± 1.47 29.0 ± 3.20 231.6 ± 58.96 6.5 ± 1.39 15.9 ± 13.67 184.9 ± 48.17 4.1 ± 1.08 10.5 ± 2.71 0.8 ± 0.10
 GT 33.3 ± 2.98 20.6 ± 2.34 0.8 ± 0.87 11.1 ± 1.62 29.6 ± 3.68 240.5 ± 61.10 6.8 ± 1.36 12.9 ± 5.93 195.6 ± 42.44 3.8 ± 0.77 10.0 ± 2.79 0.8 ± 0.10
 TT 34.4 ± 2.13 19.5 ± 1.38 1.0 ± 1.15 11.3 ± 0.63 28.3 ± 3.43 213.6 ± 33.62 5.9 ± 0.88 26.8 ± 10.57 182.5 ± 28.95 3.0 ± 0.30 11.3 ± 3.72 0.8 ± 0.09
P value 0.062 0.066 0.616 0.916 0.518 0.444 0.527 0.155 0.461 0.152 0.411 0.113
E2 (Basal) TSH (mU/L) FSH (mU/L) LH (mU/L) Prolactin (ng/mL) WBC (103/μl) Hgb (g/dl) CD3 (panT) CD4 (helper T) CD8 (suppressor) CD19 (B-cell) CD56 (NK cell)
Mean ± SD (51) Mean ± SD (93) Mean ± SD (69) Mean ± SD (63) Mean ± SD (94) Mean ± SD (113) Mean ± SD (113) Mean ± SD (92) Mean ± SD (92) Mean ± SD (92) Mean ± SD (92) Mean ± SD (108)
2612.3 ± 2633.01 2.3 ± 1.51 8.9 ± 4.72 4.9 ± 2.40 12.6 ± 5.67 7.2 ± 3.04 12.6 ± 1.39 66.0 ± 11.78 34.0 ± 8.72 29.0 ± 8.22 11.2 ± 4.61 19.7 ± 9.02
1907.2 ± 1539.73 2.2 ± 1.19 8.2 ± 3.87 4.2 ± 1.75 12.9 ± 8.29 7.2 ± 2.12 12.3 ± 1.51 66.9 ± 9.31 33.3 ± 8.71 28.9 ± 6.43 10.2 ± 3.79 21.1 ± 11.58
1500.4 1.5 6.1 5.9 11.7 9.0 12.8 N/A N/A N/A N/A N/A
  0.838 0.703 0.406 0.962 0.833 0.530 0.765 0.745 0.950 0.373 0.558
2472.7 ± 2463.80 2.3 ± 1.56 8.7 ± 4.59 4.8 ± 2.13 12.4 ± 6.08 7.2 ± 2.75 12.6 ± 1.40 65.9 ± 11.82 33.4 ± 8.99 28.9 ± 8.14 11.3 ± 4.89 20.3 ± 9.92
2675.4 ± 2485.86 2.3 ± 0.80 9.1 ± 4.44 5.2 ± 2.78 14.0 ± 6.69 7.4 ± 3.50 12.5 ± 1.54 66.8 ± 9.58 35.8 ± 7.04 29.1 ± 6.70 10.1 ± 2.21 18.8 ± 8.08
25.4 ± 28.43 1.400 5.9 ± 3.49 2.3 ± 1.77 6.100 7.1 ± 2.73 12.7 ± 0.14 70.0 ± 9.90 34.5 ± 14.85 32.5 ± 12.02 8.0 ± 1.41 22.5 ± 12.02
0.350 0.828 0.632 0.205 0.355 0.974 0.985 0.853 0.565 0.818 0.425 0.762
2,395.0 ± 2,202.59 2.4 ± 1.50 8.7 ± 4.65 4.8 ± 2.43 12.6 ± 6.57 7.2 ± 2.92 12.7 ± 1.38 65.3 ± 11.75 33.7 ± 8.33 28.8 ± 8.05 11.3 ± 4.54 20.4 ± 9.31
2812.7 ± 3516.58 1.5 ± 0.68 8.7 ± 3.90 4.8 ± 1.43 12.7 ± 4.19 7.5 ± 2.63 11.9 ± 1.40 70.2 ± 7.99 34.5 ± 10.33 30.2 ± 7.02 9.9 ± 3.96 18.0 ± 10.85
N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
0.730 0.019 0.985 0.920 0.968 0.668 0.031 0.106 0.732 0.501 0.260 0.342
2475.7 ± 2224.15 2.3 ± 1.21 7.5 ± 2.58 4.5 ± 1.87 12.7 ± 6.35 7.2 ± 2.83 12.4 ± 1.43 67.2 ± 8.90 32.6 ± 8.90 29.9 ± 7.51 10.3 ± 3.74 20.6 ± 9.91
2553.5 ± 2804.33 2.1 ± 1.22 10.1 ± 5.93 5.3 ± 2.81 12.5 ± 6.28 7.5 ± 3.06 12.7 ± 1.45 64.0 ± 15.08 35.6 ± 8.12 27.2 ± 7.75 12.7 ± 5.12 19.5 ± 9.79
1784.6 ± 2010.09 4.0 ± 4.01 10.5 ± 5.15 4.8 ± 1.70 13.0 ± 4.88 5.8 ± 1.33 13.0 ± 0.68 68.6 ± 5.06 35.6 ± 9.09 30.3 ± 10.50 9.3 ± 4.54 18.5 ± 5.21
0.745 0.535 0.023 0.540 0.984 0.329 0.255 0.762 0.273 0.283 0.030 0.756
  1. Italicized text indicates significant P values
  2. BMI, body mass index; PT, prothrombin time; aPTT, activated partial thromboplastin time; PLT, platelets; BUN, blood urea nitrogen; E2, estradiol; TSH, thyroid stimulating hormone; FSH, follicle stimulating hormone; LH, luteinizing hormone; WBC, white blood cell; Hgb, hemoglobin