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Fig. 2 | Human Genomics

Fig. 2

From: Transcriptomic analysis of monocytes from HIV-positive men on antiretroviral therapy reveals effects of tobacco smoking on interferon and stress response systems associated with depressive symptoms

Fig. 2

Overview and functional categories of differentially expressed genes in peripheral blood monocytes from HIV+ tobacco smokers vs. HIV- non-smokers. a Number of differentially expressed genes (FDR-adjusted p value < 0.15, absolute log2 FC > 0.25) (top left panel), number of enriched GO terms (p < 0.05) by ontology and direction of expression change (bottom left panel), and representative enriched GO terms for sets of up- and down-regulated genes (FDR-adjusted p value < 0.10; right panel) from models contrasting HIV+ smokers vs. non-smokers. Full expression and GO enrichment results are included in Additional file 2: Tables S1 and S2. b Average fold-change differences in HIV+ smokers and non-smokers compared with uninfected individuals (top panel) and associated GO categories for 100 selected upregulated genes mapping to significantly enriched GO terms (bottom panel). Genes with no mapped GO terms but known associations with tobacco smoking in monocytes reported in the literature (SLC2A16, SLC35B3) were included. GO, Gene Ontology; FDR, false discovery rate; TS+, tobacco smoker; TS−, non-smoker

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Human Genomics

ISSN: 1479-7364