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Fig. 3 | Human Genomics

Fig. 3

From: Transcriptomic analysis of monocytes from HIV-positive men on antiretroviral therapy reveals effects of tobacco smoking on interferon and stress response systems associated with depressive symptoms

Fig. 3

Gene expression heatmap and GO ontology of selected smoking-associated genes by HIV status and tobacco smoking. Normalized expression values from 48 selected upregulated DE genes mapping to enriched GO terms (Fig. 2) were z-scored, samples were grouped by k-means clusters (optimal k = 4) and ordered by cluster, HIV status, and smoking. Colored bars above heatmap denote HIV and smoking groups and CES-D depression scores (≥ 16 indicates risk for clinical depression [55]). Genes associated with smoking in previous studies of monocytes in the general population marked in red with asterisks. CES-D, Center for Epidemiological Studies Depression Scale; GO, Gene Ontology; TS+, tobacco smoker; TS−, non-smoker

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Human Genomics

ISSN: 1479-7364