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Fig. 4 | Human Genomics

Fig. 4

From: Investigating RNA expression profiles altered by nicotinamide mononucleotide therapy in a chronic model of alcoholic liver disease

Fig. 4

Pathway analysis and enrichment (p < 0.05) of a NMN-dependent ethanol genes and b NMN-independent ethanol genes. The top three (via p value) pathways enriched for genes with NMN-dependent ethanol effects: c amino sugar and nucleotide sugar metabolism, d steroid hormone biosynthesis, and e MAPK signaling pathway. In these heatmaps, each row represents a gene with a significant ethanol effect (FDR < 0.05) that was classified as NMN-dependent (differential ethanol p < 0.05). Expression levels are shown as the ratio of average expression level in each treatment combination (columns) to the average expression in the Control Saline group. Expression levels were log base 2 transformed prior to analyses and graphing. Values in the key have be back transformed to increase interpretability

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