Table 1 Genes from the RNA-seq dataset that have an ethanol effect 10-fold or greater (FDR < 0.05) and a differential effect of ethanol of (p < 0.0001)
Gene symbol | Gene description | Overall effect of ethanol FDR (unadjusted p value) | Differential effect of ethanol in NMN and saline groups FDR (unadjusted p value) | Ethanol effect in saline group (ethanol expression as percent of control expression) | Ethanol effect in NMN group (ethanol expression as percent of control expression) |
|---|---|---|---|---|---|
Hmox1 | Heme oxygenase 1 | 3.6e−135 (2.6e−139) | 3.6e-20 (3.4e−24) | 1902% | 328% |
Nr4a1 | Nuclear receptor subfamily 4 | 4.9e−26 (4.9e−29) | 1.0e-06 (2.9e−10) | 1057% | 123% |
Trib3 | Tribbles pseudokinase 3 | 3.2e−54 (9.2e−58) | 4.0e-06 (1.5e−09) | 1483% | 281% |
Atf3 | Activating transcription factor 3 | 2.6e−23 (3.2e−26) | 1.7e-02 (3.9e−05) | 3711% | 522% |
Clec2h | C-type lectin domain family 2 | 1.3e−10 (1.0e−12) | 1.9e-02 (5.2e−05) | 9% | 69% |