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Table 1 Summary of LRF/ZBTB7A functions in cancer. The protein is notorious for exerting tissue- and context-dependent oncogenic or oncosuppressive functions, through multiple molecular interactions

From: The multi-faceted functioning portrait of LRF/ZBTB7A

CancerFunctionMolecular partnersBiological processReference
LymphomaOncogenicBCL6‚ p19ArfCell transformation, cell growth38
Acute myeloid leukemiaOncogenicRUNX1/RUNX1T1Proliferation39
Lung cancerOncogenicmiR-125a, miR-520eCell cycle, cell growth, proliferation, apoptosis, invasion40-43, 69, 85
OncosuppressiveHP1γ, AXL, PVT1, ELK1Proliferation, migration88
Hepatocellular carcinomaOncogenicmiR-125, miR-137, MEF2D, p53, p21,p27, cyclins, CDKs, PI3K/AKT, RAS/RAF/MEK/ERK, BCL2, FAS receptor, FADD, caspase-8, caspase-10Cell cycle, proliferation, apoptosis, migration/metastasis, invasion37, 44-48, 65, 66
OncosuppressivemiR-106bProliferation, apoptosis83
Prostate cancerOncogenicSTRN4, EGFProliferation, apoptosis49, 50, 79
OncosuppressiveSox9, ARSenescence, proliferation, invasion89, 92
Ovarian cancerOncogenicMT1-MMPMigration/metastasis, invasion51
Breast cancerOncogenicSurvivin, SP1,Smad4Proliferation, apoptosis52-55, 77
Gastric cancerOncogenicC/EBPα/ miR-100Proliferation, migration/metastasis55
OncosuppressiveNot definedCell cycle, apoptosis, migration/metastasis95
GliomaOncogenicAKT, cyclins, CDKs, NF-κB, SurvivinCell cycle, proliferation, apoptosis, migration/metastasis56
Sarcoma/mesenchymal tumorsOncogenicp21, p53, miR-663a, LncRNA GAS5, circular RNA of LRF/ZBTB7A - ILF2/3Cell cycle, proliferation, apoptosis, migration/metastasis, invasion, angiogenesis57, 58, 68, 103
OncosuppressiveDLK1, Sox9Cell transformation, proliferation93, 103
Colorectal cancerOncogenicDAP5/p53, ETS-1Cell cycle, proliferation, apoptosis, migration/metastasis, invasion59-62
Renal carcinomaOncogenicmiR-137Proliferation, invasion63
Liver cancerOncogenicmiR-21, Sprouty1Cell growth, proliferation84
Bladder cancerOncogenicTGF-βCell growth, migration/metastasis, invasion81
MelanomaOncosuppressiveMCAMMigration/metastasis96