Delineating significant genome-wide associations of variants with antipsychotic and antidepressant treatment response: implications for clinical pharmacogenomics

Table 1 Functional annotation of the five identified missense variants within the psychiatric pharmacogenomics GWAS studies of interest in this study

Variant type	rsID	Gene	Drug correlation	Protein damaging pred. (SIFT^*, Polyphen2^#)
missense	rs4314643	NMNAT2	Clozapine	Benign (0.13, 0.232)
missense	rs2236295	ADO	Venflaxine	Benign (0.74, 0.007)
missense	rs17815774	TRPM1	Risperidone	Benign (0.07, 0.191)
missense	rs2307441	POLG	Venlafaxine	Benign (0.16, 0.334)
missense	rs17727261	CNTNAP5	Risperidone	Benign (0.06, 0.006)

SIFT and Polyphen2 are in silico tools used to assess the protein damaging effect of missense variants
*SIFT score for protein damaging prediction (< 0.05; deleterious)
^#Polyphen2 score for deleterious variants ( > 0.908; probably damaging, 0.446 < score ≤ 0.908; possibly damaging)

ISSN: 1479-7364