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Fig. 4 | Human Genomics

Fig. 4

From: Hyperinsulinism associated with GLUD1 mutation: allosteric regulation and functional characterization of p.G446V glutamate dehydrogenase

Fig. 4

Molecular structures of GDH-wt and GDH-G446V subunit. Single subunit of GDH (side view, blue) with highlighted glycine-446 (yellow) in wtGDH (arrow a, b) and 446-valine (yellow) in GDH-G446V (arrow c, d) on the descending helix in opened (a, c) and closed (b, d) conformation. The pivot helix of the GDH-G446V shows a different conformation in the closed state (b, d) versus the GDH-wt

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Human Genomics

ISSN: 1479-7364