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Table 13 Comparison of significance obtained in this study compared to previous GWAS. P values from GWAS presented as from the original paper. Pun = uncorrected P value; PC = corrected p value. Baranzini et al. presented their significance as adjusted log P values

From: An investigation of genetic polymorphisms in heparan sulfate proteoglycan core proteins and key modification enzymes in an Australian Caucasian multiple sclerosis population

  

Genotype (%)

Allele (%)

Current study

GWAS significance

Gene

SNP

Hom (%)

Het (%)

Var (%)

Allele 1

Allele 2

P value

Corrected B-H

Corrected Bonferroni

Cenit 2009 Pun (PC)

Baranzini 2009

Adj Log p value

Lorentzen 2010

Pun

GPC5

rs7333912

95.1

4.9

0

97.6

2.4

0.76

0.878

1

  

0.02

GPC5

rs10492503

32.8

48.1

19.1

56.8

43.2

0.016

0.08

0.128

0.016 (0.096)

  

GPC5

rs9523787

71.2

26.3

2.5

84.4

15.6

0.069

0.812

1

  

0.0002

GPC5

rs9523762

Did not follow Hardy-Weinburg equilibrium

 

5.155

 

GPC6

rs17267815

22.4

51.2

26.4

48.1

51.9

0.0797

0.213

0.638

  

0.03

GPC6

rs9524260

38.6

45.7

15.7

61.4

38.6

0.236

0.472

1

  

0.10