Table 3 Genotype and allele frequencies of EXT-1 SNP (rs11546829) within the case-control MS population which is further subdivided into disease states. Corrected P values using the Benjimini-Hochberg (PBH) and Bonferroni (PBon) methods are presented below the uncorrected P value
| Â | EXT1-829 | rs11546829 | |||||||
|---|---|---|---|---|---|---|---|---|---|
Polymorphism | Genotypes | Â | Alleles | ||||||
Group | GG (%) | GA (%) | AA (%) | P(PBH, PBon) | HWE | G (%) | A (%) | P | OR (95% CI) |
MS total cases (n= 176) | 80 (45.5) | 78 (44.3) | 18 (10.2) | 0.45 (0.72, 1) | 0.87 | 238 (67.6) | 114 (32.4) | 0.75 | 0.95 |
PP case (n= 49) | 22 (44.9) | 22 (44.9) | 5 (10.2) | 0.67 | Â | 66 (67.3) | 32 (32.7) | 0.87 | 0.96 |
SP case (n= 43) | 21 (48.8) | 19 (44.2) | 3 (7) | 0.45 | Â | 61 (70.9) | 25 (29.1) | 0.44 | 0.81 |
RR case (n= 84) | 37 (44) | 37 (44) | 10 (12) | 0.72 | Â | 111 (66.1) | 57 (51.4) | 0.94 | 1.02 |
Control (n= 134) | 63 (47) | 52 (38.9) | 19 (14.2) | – | 0.13 | 178 (66.4) | 90 (33.6) | – | – |
HapMap CEU (%) | 58.3 | 36.7 | 5 | Â | Â | 76.7 | 23.3 | Â | Â |