Skip to main content

Table 4 Genotype and allele frequencies in the case-control MS population for the SULF-1 SNP (rs262347) further subdivided into disease states. Corrected p values using the Benjimini-Hochberg (PBH) and Bonferroni (PBon) methods are presented below the uncorrected P value

From: An investigation of genetic polymorphisms in heparan sulfate proteoglycan core proteins and key modification enzymes in an Australian Caucasian multiple sclerosis population

 

SULF1

rs2623047

Polymorphism

Genotypes

 

Alleles

Group

CC (%)

CT (%)

TT (%)

P

(PBH, PBon)

HWE

C (%)

T (%)

P

OR (95% CI)

MS total cases (n= 190)

21 (11.1)

84 (44.2)

85 (44.7)

0.94 (0.94, 1)

0.97

126 (33.2)

254 (66.8)

0.94

1.01

PP case (n= 50)

7 (14)

20 (40)

23 (46)

0.68

 

34 (34)

66 (66)

0.92

0.97

SP case(n= 46)

8 (17.4)

18 (39.1)

20 (43.5)

0.40

 

34 (37)

58 (63)

0.53

0.86

RR case (n= 94)

6 (6.4)

46 (48.9)

42 (44.7)

0.53

 

58 (30.9)

130 (69.1)

0.54

1.13

Control (n= 172)

18 (10.5)

79 (45.9)

75 (43.6)

–

0.68

115 (33.4)

229 (66.6)

–

–

HapMap CEU (%)

15.9

51.3

32.7

  

41.6

58.4

 Â