Table 5 Results by disease state for SDC1 SNP (rs1131351) and of the MS case-control population. Corrected P values using the Benjimini-Hochberg (PBH) and Bonferroni (PBon) methods are presented below the uncorrected P value
| Â | SDC 1 | rs113151 | |||||||
|---|---|---|---|---|---|---|---|---|---|
Polymorphism | Genotypes | Â | Alleles | ||||||
Group | GG (%) | GC (%) | CC (%) | P (PBH, PBon) | HWE | G (%) | C (%) | P | OR (95% CI) |
MS total cases (n= 160) | 31 (19.4) | 83 (51.9) | 46 (28.8) | 0.02 (0.08, 0.16) | 0.55 | 145 (45.3) | 175 (54.7) | 0.004 | 1.59 |
PP case (n= 45) | 8 (17.8) | 24 (53.3) | 13 (28.9) | 0.11 | Â | 40 (44.4) | 50 (55.6) | 0.04 | 1.65 |
SP case (n= 39) | 8 (20.5) | 19 (48.7) | 12 (30.8) | 0.15 | Â | 35 (44.9) | 43 (55.1) | 0.06 | 1.62 |
RR case (n= 76) | 15 (19.7) | 40 (52.6) | 21 (27.6) | 0.09 | Â | 70 (46.1) | 82 (53.9) | 0.03 | 1.55 |
Male (n= 31) | 7 (22.6) | 17 (54.8) | 7 (22.6) | 0.58 | Â | 31 (50) | 31 (50) | 0.32 | 1.32 |
Female (n= 129) | 24 (18.6) | 66 (51.2) | 39 (30.2) | 0.01 | Â | 114 (44.2) | 144 (58.8) | 0.003 | 1.67 |
Total control (n= 145) | 46 (31.7) | 73 (50.3) | 26 (17.9) | – | 0.75 | 165 (56.9) | 125 (43.1) | – |  |
HapMap CEU (%) | 50 | 31 | 19 | Â | Â | 65.5 | 34.5 | Â | Â |