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Table 3 NIPT results in total samples and AMA women samples

From: Clinical performance of non-invasive prenatal served as a first-tier screening test for trisomy 21, 18, 13 and sex chromosome aneuploidy in a pilot city in China

NIPT

Total samples

AMA women

T21

T18

T13

SCAs

Total

T21

T18

T13

SCA

Total

Total positive cases

87

31

22

141

281

40

13

7

29

89

Frequency

1/493

1/1385

1/1951

1/304

1/153

1/228

1/703

1/1305

1/315

1/103

TP

51

17

2

51

121

26

4

1

13

44

FP

14

10

18

57

99

4

1

4

10

19

PPV`

78.46%

62.96%

10.00%

47.22%

55.00%

86.67%

80.00%

20.00%

56.52%

69.84%

  1. TP true positive, FP false-positive, PPV positive predictive value, T21 trisomy 21, T18 trisomy 18; T13 trisomy 13; SCAs sex chromosomal aneuploidies, AMA advanced maternal age
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Human Genomics

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