Fig. 3
Comparison of transcriptional response controlling for cell-type. Differentially expressed genes were identified for HepG2 cells exposed to 1 μM ethinyl estradiol (EE2), 10 nM 2,3,7,8-tetrachlorodibenzodioxin (TCDD), 5 μM diethylstilbestrol (DES), 1 μM bisphenol A (BPA), or 1 μM genistein (GEN) for 6 h or 30 μM estradiol (E2) for 12 h. a The chemical structures of E2, EE2, TCDD, DES, BPA, and GEN were created using Chemdraw 18.0. b The xenoestrogen-regulated genes in HepG2 cells were compared by a Venn diagram to identify unique and commonly regulated genes. c The top 10 induced and repressed genes are listed by chemical. d A comparison analysis of the top canonical pathways utilizing the predicted activation z score. e A comparison analysis of the top molecular and cellular functions utilizing the predicted activation z score. f Induced (red) and repressed (green) molecules associated with the “Estrogen Receptor Signaling” pathway visualized for each chemical