Skip to main content

Table 3 Significantly enriched pathway

From: Whole-genome sequencing of Chinese centenarians reveals important genetic variants in aging WGS of centenarian for genetic analysis of aging

Gene set name[#Genes(K)]Description#Genes in Overlap(k)p valueFDR q value
REACTOME_INTERFERON_GAMMA_SIGNALING[63]Interferon gamma signaling52.61E−092.81E−06
KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION[89]Antigen processing and presentation51.52E−088.16E−06
KEGG_ALLOGRAFT_REJECTION[38]Allograft rejection43.55E−081.28E−05
KEGG_GRAFT_VERSUS_HOST_DISEASE[42]Graft-versus-host disease45.35E−081.40E−05
KEGG_TYPE_I_DIABETES_MELLITUS[44]Type I diabetes mellitus46.51E−081.40E−05
KEGG_CELL_ADHESION_MOLECULES_CAMS[134]Cell adhesion molecules (CAMs)51.19E−072.13E−05
KEGG_AUTOIMMUNE_THYROID_DISEASE[53]Autoimmune thyroid disease41.40E−072.15E−05
REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE[14]Translocation of ZAP-70 to immunological synapse32.21E−072.97E−05
REACTOME_INTERFERON_SIGNALING[159]Interferon signaling52.78E−073.32E−05
REACTOME_PHOSPHORYLATION_OF_CD3_AND_TCR_ZETA_CHAINS[16]Phosphorylation of CD3 and TCR zeta chains33.39E−073.66E−05
\