Skip to main content

Table 1 Summary of reported associations between human genes and COVID-19

From: Human genetic factors associated with susceptibility to SARS-CoV-2 infection and COVID-19 disease severity

Gene(s) Polymorphism(s) Chromosome location Reported COVID-19 associations Reference(s)
ABO rs657152 9q34.2 Higher risk of infection for blood group A vs. non-A (OR 1.45, 95% CI 1.20–1.75, P = 1.48 × 10−4) and lower risk of infection for blood group O vs. non-O (OR 0.65, 95% CI 0.53–0.79, P = 1.06 × 10−5) [7, 38, 39]
ACE2 p.Arg514-Gly Xp22.2 Cardiovascular and pulmonary conditions in the African/African-American population by altering AGT-ACE2 pathway [49]
ApoE rs429358-C-C (e4e4) 19q13.32 Severe disease independently of pre-existing dementia, cardiovascular disease, and type 2 diabetes [32]
HLA B*46:01 and B*15:03 6p21.33 Vulnerable to disease for HLA-B*46:01 and cross-protective T cell-based immunity for HLA-B*15:03 [15]
IFITM3 rs12252-C/C 11p15.5 Mild-to-moderate disease requiring hospitalization [35]
SLC6A20, LZTFL1, CCR9, FYCO1, CXCR6, XCR1 rs11385942-GA 3p21.31 Severe disease (respiratory failure) (OR 1.77, 95% CI 1.48–2.11, P = 1.15 × 10−10) [7]
TLR7 g.12905756_12905759del and g.12906010G>T Xp22.2 Severe disease [19]
TMEM189-UBE2V1 rs6020298-A 20q13.13 Severe disease [17]
TMPRSS2 p.Val160Met (rs12329760) 21q22.3 Increased susceptibility to disease and for risk factors, e.g., cancer [49]