Skip to main content
Fig. 4 | Human Genomics

Fig. 4

From: Microarray analysis identification of key pathways and interaction network of differential gene expressions during osteogenic differentiation

Fig. 4

Model of PI3K/AKT regulation and Wnt/β-catenin in osteogenic differentiation. Important pathways in osteoblast that promote osteogenesis via PI3K/AKT and β-catenin. a PI3K/AKT and its relationship with growth factors, ECM attachment, IGF1, IGF2, LPS, and BMP2 are illustrated in the top portion of this figure. The question mark next to PI3K/AKT/NF-κB indicates whether PI3K/AKT plays a significant role during osteogenesis directly via BMP2 signaling or indirectly through the upregulation of NF-κB. b The interaction or connections of genes and pathways with β-catenin are shown. Wnt/β-catenin interacts or is affected by FGF, IGF-1/IGF-2, IGFBP7, VEGF, integrin-ILK, ITGA11/β1, ITGA5/β1, CDH11, ERK/MAPK, PI3K/AKT, IL-6, and adiponectin. The red star represents commonly upregulated genes on all 3 days. Only expression of MAPK3 (ERK1) at day 8, ITGA5 on days 8 and 25, and both IGFBP7 and ITGA11 at day 25 are represented. ECM, extracellular matrix; PI3K, phosphoinositide 3-kinase; MKK, MAP kinase kinases

Back to article page

Human Genomics

ISSN: 1479-7364