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Fig. 2 | Human Genomics

Fig. 2

From: KVarPredDB: a database for predicting pathogenicity of missense sequence variants of keratin genes associated with genodermatoses

Fig. 2

Example outputs of KVarPredDB. a A lollipop diagram is displayed to show the distribution of all the missense sequence variations on a linearized K10 protein and its domains. Y-axis represents K10 sequence variant frequency. b Structural analyses in terms of physico-chemical properties, inter/intra-chain interactions, evolutionary conservation, and location in heptad repeats. c Visualization of ddg score generated by molecular docking simulation (box plot) and structural alignment (GIF format) between the wild type and mutant keratin coiled-coil heterodimer. d Screenshot of K5/K14 heterodimer coiled-coil complex structure (3TNU) in the “NGL Viewer” GUI

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Human Genomics

ISSN: 1479-7364