Table 5 Haplotype analysis for association of TNFSF4 gene polymorphisms with scleritis
From: The haplotypes of various TNF related genes associated with scleritis in Chinese Han
|  | Haplotypea | Cases (%) | Controls (%) | χ2 | P value | Pc value | OR (95% CI) |
|---|---|---|---|---|---|---|---|
Scleritis | AG | 316.16 (0.312) | 429.09 (0.315) | 0.019 | 0.891 | NS | 0.988 (0.829~1.177) |
AT | 527.84 (0.522) | 730.91 (0.537) | 0.529 | 0.467 | NS | 0.941 (0.800~1.108) | |
GG | 88.84 (0.088) | 136.91 (0.101) | 1.094 | 0.296 | NS | 0.861 (0.651~1.140) | |
GT | 79.16 (0.078) | 65.09 (0.048) | 9.419 | 0.002 | 0.004 | 1.691 (1.205~2.372) | |
Scleritis subgroups | |||||||
 Anterior scleritis | GT | 49.77 (0.076) | 65.09 (0.048) | 6.505 | 0.011 | 0.022 | 1.636 (1.117~2.396) |
 Posterior scleritis | GT | 16.06 (0.065) | 65.09 (0.048) | 1.259 | 0.262 | NS | 1.379 (0.785~2.424) |
 Pan-scleritis | GT | 9.17 (0.158) | 65.09 (0.048) | 13.678 | 2.19 × 10−4 | 4.38 × 10−4 | 3.744 (1.772~7.910) |
 Scleritis without systemic disease | GT | 72.27 (0.079) | 65.09 (0.048) | 9.607 | 0.002 | 0.004 | 1.719 (1.216~2.430) |
 Scleritis with systemic disease | GT | 6.70 (0.066) | 65.09 (0.048) | 0.655 | 0.418 | NS | 1.402 (0.616~3.188) |