Table 6 Haplotype analysis for association of TNFSF15 gene polymorphisms with scleritis
From: The haplotypes of various TNF related genes associated with scleritis in Chinese Han
|  | Haplotypea | Cases (%) | Controls (%) | χ2 | P value | Pc value | OR (95% CI) |
|---|---|---|---|---|---|---|---|
Scleritis | CCC | 71.22 (0.080) | 61.93 (0.051) | 8.122 | 0.004 | 0.012 | 1.662 (1.168~2.363) |
CCT | 126.33 (0.143) | 187.89 (0.154) | 0.342 | 0.559 | NS | 0.930 (0.728~1.187) | |
CTC | 417.41 (0.471) | 573.14 (0.470) | 0.148 | 0.701 | NS | 1.035 (0.869~1.232) | |
CTT | 37.05 (0.042) | 58.03 (0.048) | 0.308 | 0.579 | NS | 0.888 (0.582~1.353) | |
TCC | 217.94 (0.246) | 335.10 (0.275) | 1.63 | 0.202 | NS | 0.879 (0.721~1.072) | |
Scleritis subgroups | |||||||
 Anterior scleritis | CCC | 51.62 (0.089) | 61.93 (0.051) | 10.319 | 0.001 | 0.003 | 1.860 (1.267~2.730) |
 Posterior scleritis | CCC | 13.82 (0.065) | 61.93 (0.051) | 0.87 | 0.351 | NS | 1.331 (0.729~2.432) |
 Pan-scleritis | CCC | – | – | – | – | – | – |
 Scleritis without systemic disease | CCC | 61.54 (0.077) | 61.93 (0.051) | 6.113 | 0.013 | 0.039 | 1.579 (1.096~2.274) |
 Scleritis with systemic disease | CCC | 9.98 (0.116) | 61.93 (0.051) | 6.832 | 0.009 | 0.027 | 2.496 (1.229~5.067) |