Fig. 1

Alu polymorphism within ACE intron 16 influences circulating ACE enzyme. ACE II, ID, and DD are three ACE genotypes generated by Alu insertion/deletion events. These genotypes affect the circulating level of ACE encoded by the gene. Specifically, individuals with the II genotype have the lowest circulating ACE levels whereas individuals having the DD genotype tend to have the highest-circulating ACE level. I, insertion; D, deletion