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Table 1 Susceptibility genes of type 1 AIH

From: Genetic risk factors for autoimmune hepatitis: implications for phenotypic heterogeneity and biomarkers for drug response

 

Susceptibility genes or alleles (protective alleles are underlined)

Populations

References

GWAS

DRB1*03:01, DRB1*04:01, SH2B3, CARD10

European

[34]

Candidate gene approach

DRB1*03:01, DRB1*04:01, DRB1*15:01

European

[35,36,37,38]

DRB1*04:01, DRB1*04:05, DRB1*13:02, DRB1*15:01, DRB1*04/DRB1*08

Japanese

[39,40,41,42,43,44]

DRB1*04:04, DRB1*04:05, DRB1*13:01, DRB1*13:02

Hispanic

[45,46,47,48,49,50,51]

 

DRB1*04:05

Korean

[52]

 

DRB1*01, DRB1*04, DRB1*08, DRB1*14

Indian, Iranian

[53,54,55]

 

DRB1*13, DRB1*14

Pakistani

[56]

 

DP5 (rs9277534G)

Japanese

[57]

 

KIR

European

[58, 59]

 

PTPN22

Japanese

[60]

 

SH2B3

Japanese

[61]

 

TNFAIP3

Japanese

[62]

 

STAT4

Japanese

[63]

 

TNIP1

Japanese

[64]

 

CTLA4, ICOS

European, Japanese

[65,66,67]

 

FAS

European, Japanese

[68, 69]

 

TNF

European

[70, 71]

  1. AIH autoimmune hepatitis, GWAS genome-wide association study