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Fig. 3 | Human Genomics

Fig. 3

From: Comprehensive assessments of germline deletion structural variants reveal the association between prognostic MUC4 and CEP72 deletions and immune response gene expression in colorectal cancer patients

Fig. 3

The frequency spectrum of DSVs in cancer and non-cancer subjects and germline cancer susceptibility gene analysis. a Bar plot of the top 10 DSV genes with significant odds ratios and p-adjusted values < 0.05 by the false discovery rate (FDR) in the cancer group and non-cancer group separately. The x-axis indicates the percentage of subjects who carry DSV genes, while the y-axis represents the DSV genes. b Heatmap of 57 DSV genes and clinical information. Genes with an odds ratio and p-adjusted value < 0.05 by the FDR were selected. The clinical information includes sex, age, and FCH. c Bar plot of 26 DSV genes intersected in 565 germline cancer susceptibility genes in cancer and non-cancer subjects. The x-axis indicates the well-known cancer susceptibility genes, and the y-axis indicates the frequency of the genes in cancer and non-cancer subjects. FANCA, POLD1, and STK11 gene deletions occurred only in the cancer group

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