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Fig. 4 | Human Genomics

Fig. 4

From: Comprehensive assessments of germline deletion structural variants reveal the association between prognostic MUC4 and CEP72 deletions and immune response gene expression in colorectal cancer patients

Fig. 4

DSV genes and survival analysis in cancer patients with or without family cancer history. a Table of the association between cancer and FCH. The subjects who had FCH had a higher risk of developing cancer 1.89 [1.33–2.68] than the subjects without FCH (Fisher’s exact test p = 0.0003). The family cancer history is related to first- and second-degree relatives of patients with any cancer. b Fisher’s exact test and odds ratio were applied to measure the relationship between each DSV gene and FCH. Forest plot of cancer patients with and without FCH. The DSV genes are SMYD3 and NKD2 in cancer patients with FCH. The DSV genes are MGAT4C, HSPA4L, ZSCAN5A, LOC100505841, and NALCN in cancer patients without FCH. c Forest plot of non-cancer subjects with and without FCH. The DSV genes are MALRD1, LOC101928523, and RAB9BP1 in non-cancer subjects with FCH. There are nine DSV genes in non-cancer subjects without FCH. d Point plot of the log2 hazard ratio DSV genes and log10 (p value). The size of the point indicates the frequency of the DSV gene in cancer subjects, and the red marks indicate the eight DSV genes with a p value < 0.05. Blue points (MUC4 and CEP72 gene deletions) show the validated results

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Human Genomics

ISSN: 1479-7364